Evidence map›Paper›PMID 38364863›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Intestinal Permeability, Gut Inflammation, and Gut Immune System Response Are Linked to Aging-Related Changes in Gut Microbiota Composition: A Study in Female Mice.

Paola Elizabeth Gámez-Macías, Elisa Félix-Soriano, Mirian Samblas, Neira Sáinz, María Jesús Moreno-Aliaga, Pedro González-Muniesa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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  17. Sea Buckthorn Fermented Milk withFoods (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Paola Elizabeth Gámez-MacíasFaculty of Pharmacy and Nutrition, Department of Nutrition, Food Science, and Physiology, University of Navarra, Pamplona, Spain.ORCID 0000-0001-8627-8537
Elisa Félix-SorianoFaculty of Pharmacy and Nutrition, Department of Nutrition, Food Science, and Physiology, University of Navarra, Pamplona, Spain.
Mirian SamblasCenter for Nutrition Research, University of Navarra, Pamplona, Spain.
Neira SáinzCenter for Nutrition Research, University of Navarra, Pamplona, Spain.
María Jesús Moreno-AliagaFaculty of Pharmacy and Nutrition, Department of Nutrition, Food Science, and Physiology, and Center for Nutrition Research, University of Navarra/Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Pedro González-MuniesaFaculty of Pharmacy and Nutrition, Department of Nutrition, Food Science, and Physiology, and Center for Nutrition Research, University of Navarra/Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Universidad de Navarra · ESInstituto de Salud Carlos III · ES

Funding

CIBER Physiopathology of Obesity and Nutrition (CIBEROBN) of Carlos III Health Research Institute CB12/03/30002Department of University, Innovation and Digital Transformation, Government of Navarra PI026 BIOAGEMTMINECO/FEDER of the Government of Spain BFU2015-65937-R
6 · The paper itself

Abstract

Aging entails changes at the cellular level that increase the risk of various pathologies. An association between gut microbiota and age-related diseases has also been attributed. This study aims to analyze changes in fecal microbiota composition and their association with genes related to immune response, gut inflammation, and intestinal barrier impairment. Fecal samples of female mice at different ages (2 months, 6 months, 12 months, and 18 months) and gene expression in colon tissue were analyzed. Results showed that the older mice group had a more diverse microbiota than the younger group. Additionally, the abundance of Cyanobacteria, Proteobacteria, Flavobacteriaceae, Bacteroides, Parabacteroides, Prevotellaceae_UCG-001, Akkermansia, and Parabacteroides goldsteinii increased with age. In contrast, there was a notable decline in Clostridiaceae, Lactobacillaceae, Monoglobaceae, Ligilactobacillus, Limosilactobacillus, Mucispirillum, and Bacteroides faecichinchillae. These bacteria imbalances were positively correlated with increased inflammation markers in the colon, including Tnf-α, Ccl2, and Ccl12, and negatively with the expression of tight junction genes (Jam2, Tjp1, and Tjp2), as well as immune response genes (Cd4, Cd72, Tlr7, Tlr12, and Lbp). In conclusion, high levels of diversity did not result in improved health in older mice; however, the imbalance in bacteria abundance that occurs with aging might contribute to immune senescence, inflammation, and leaky gut disease.

Indexed as

Gastrointestinal MicrobiomeAgingAnimalsBacteriaFemaleImmunityInflammationIntestinal Barrier FunctionMiceMice, Inbred C57BLColonDiversityGut microbiotaImmune responseIntestinal barrier

Identifiers

PMID38364863
PMCPMC10957128
OpenAlexW4391902797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.