Evidence map›Paper›PMID 38364511›Full record

ArticleHearing research2024

Long-term training alters response dynamics in the aging auditory cortex.

Jonah K Mittelstadt, Kelson V Shilling-Scrivo, Patrick O Kanold

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jonah K MittelstadtDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biology, University of Maryland, College Park, MD 20742, USA.
Kelson V Shilling-ScrivoDepartment of Biology, University of Maryland, College Park, MD 20742, USA; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21230, USA.
Patrick O KanoldDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biology, University of Maryland, College Park, MD 20742, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: pkanold@jhu.edu.
University of Maryland, Baltimore · US

Funding

Speech Perception with High Cognitive DemandP01AG055365 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI GORDON-SALANT, SANDRA M · 2017 to 2021
$8.4M
Training Program in NeuroscienceT32NS091018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAMES J KNIERIM, Daniel Hans O'Connor · 2015 to 2026
$4.1M
Cell type specific vulnerability to agingRF1AG078378 · NIA · JOHNS HOPKINS UNIVERSITY · PI PATRICK O KANOLD, JUSTUS M KEBSCHULL · 2023 to 2026
$4.0M
Dynamic processing of sound in auditory cortexR01DC017785 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O · 2021 to 2025
$2.7M
NIA NIH HHS P01 AG055365NIA NIH HHS RF1 AG078378NIDCD NIH HHS R01 DC017785NINDS NIH HHS T32 NS091018
6 · The paper itself

Abstract

Age-related auditory dysfunction, presbycusis, is caused in part by functional changes in the auditory cortex (ACtx) such as altered response dynamics and increased population correlations. Given the ability of cortical function to be altered by training, we tested if performing auditory tasks might benefit auditory function in old age. We examined this by training adult mice on a low-effort tone-detection task for at least six months and then investigated functional responses in ACtx at an older age (∼18 months). Task performance remained stable well into old age. Comparing sound-evoked responses of thousands of ACtx neurons using in vivo 2-photon Ca

Indexed as

Auditory CortexPresbycusisAcoustic StimulationAgingAnimalsAuditory PerceptionHearingMiceSoundAuditory cortexCortical plasticityNeuroplasticityResponseTraining

Identifiers

PMID38364511
PMCPMC11186583
OpenAlexW4391294347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.