ReviewDermatology practical & conceptual2024
Diagnostic Significance of Neutrophil to Lymphocyte Ratio in Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis.
Review in Dermatology practical & conceptual, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- The Relationship Between Severity of Apical Periodontitis and Next-Generation Systemic Inflammatory Biomarkers.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Platelet-to-lymphocyte ratio and mean platelet volume in recurrent aphthous stomatitis: Systematic review and meta-analysis of group differences.Journal of Taibah University Medical Sciences · 2026Review
- Association Between Early Childhood Caries and Systemic Inflammatory Profiles: A Retrospective Analysis of Children Undergoing Dental Treatment Under General Anesthesia.Children (Basel, Switzerland) · 2026Article
- Inflammatory Markers and Dyslipidemia in Patients with Oral Lichen Planus: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2025Article
- Evaluation of Systemic Inflammation in Children with Untreated Dental Caries.Oral health & preventive dentistry · 2025Article
- Neutrophils: emerging perspectives on the pathogenesis of oral mucosal diseases.Frontiers in cellular and infection microbiology · 2025Review
- The relationship between severity of periapical periodontitis and next-generation systemic inflammatory biomarkers in children with early childhood caries.BMC oral health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecurrent aphthous stomatitis (RAS) is a prevalent ulcerative condition affecting oral mucosa.
objectivesA systematic review and meta-analysis was performed to compare the level of neutrophil to lymphocyte ratio (NLR) between individuals with RAS and those who are healthy.
methodsA systematic search for relevant publications before June 21, 2022, was conducted using Web of Science, PubMed, and Scopus. The results were presented as the standardized mean difference (SMD) with a 95% confidence interval (CI), and a random-effects model was used to calculate pooled effects due to the presence of significant heterogeneity. Quality assessment was performed using the Newcastle-Ottawa scale.
resultsOverall, 13 article with were included in the analysis. NLR was higher among patients with RAS compared to healthy controls (SMD = 0.50, 95% CI = -0.20 to 0.79, P = 0.001, I
conclusionElevated neutrophil to lymphocyte ratio revealed crosstalk between systematic inflammation and RAS.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.