Evidence map›Paper›PMID 38364254›Full record

ArticleAging2024

Prognostic value and therapeutic potential of IAP family in head and neck squamous cell carcinoma.

Xiaoqian Yu, Weiwei Cao, Xuejie Yang, Canping Yu, Wenying Jiang, Hongbin Guo, Xiaoyun He, Cheng Mei, Chunlin Ou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaoqian YuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Weiwei CaoDepartment of Blood Transfusion, Xiangya Hospital, Clinical Transfusion Research Center, Central South University, Changsha 410008, Hunan, China.
Xuejie YangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Canping YuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Wenying JiangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Hongbin GuoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Xiaoyun HeDepartments of Ultrasound Imaging, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Cheng MeiDepartment of Blood Transfusion, Xiangya Hospital, Clinical Transfusion Research Center, Central South University, Changsha 410008, Hunan, China.
Chunlin OuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) ranks as the eighth most prevalent malignancy globally and has the eighth greatest fatality rate when compared to all other forms of cancer. The inhibitor of apoptosis protein (IAP) family comprises a collection of apoptosis-negative modulators characterized by at least one single baculovirus IAP repeat (BIR) domain in its N-terminal region. While the involvement of the IAP family is associated with the initiation and progression of numerous tumours, its specific role in HNSCC remains poorly understood. Thus, this study aimed to comprehensively examine changes in gene expression, immunomodulatory effects, prognosis, and functional enrichment of HNSCC utilising bioinformatics analysis. Elevated levels of distinct IAP family members were observed to varying degrees in HNSCC, with high BIRC2 expression indicating a worse prognosis. Additionally, Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to probe the enrichment of gene expression and biological processes related to the IAP family in HNSCC. The infiltration levels of immune cells were shown to be strongly associated with the IAP gene expression, as determined by subsequent analysis. Hence, BIRC2 could be an effective immunotherapy target for HNSCC. Collectively, novel knowledge of the biological roles and prognostic implications of IAP family members in HNSCC is presented in this study.

Indexed as

Head and Neck NeoplasmsBiomarkers, TumorGene Expression Regulation, NeoplasticHumansInhibitor of Apoptosis ProteinsPrognosisSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorInhibitor of Apoptosis Proteinshead and neck squamous cell carcinomaIAP familyimmune cellsimmune targetsprognosis

Identifiers

PMID38364254
PMCPMC10929838
OpenAlexW4391823669

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.