ArticleProceedings of the National Academy of Sciences of the United States of America2024
Phosphorylation of the alpha-I motif in SYMRK drives root nodule organogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026Review
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Heterologous expression of nodulation signaling pathway genes enhances grain yield in rice.Plant molecular biology · 2025Article
- Differential phosphorylation of receptor kinase SlLYK4 mediates immune responses to bacterial and fungal pathogens in tomato.Science advances · 2025Article
- Functional Characterization of Ammonium TransporterJournal of fungi (Basel, Switzerland) · 2025Article
- Understanding the Crucial Role of Phosphate and Iron Availability in Regulating Root Nodule Symbiosis.Plant & cell physiology · 2024Review
- A conserved juxtamembrane motif in plant NFR5 receptors is essential for root nodule symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Symbiosis receptor-like kinase SYMRK is required for root nodule symbiosis between legume plants and nitrogen-fixing bacteria. To understand symbiotic signaling from SYMRK, we determined the crystal structure to 1.95 Å and mapped the phosphorylation sites onto the intracellular domain. We identified four serine residues in a conserved "alpha-I" motif, located on the border between the kinase core domain and the flexible C-terminal tail, that, when phosphorylated, drives organogenesis. Substituting the four serines with alanines abolished symbiotic signaling, while substituting them with phosphorylation-mimicking aspartates induced the formation of spontaneous nodules in the absence of bacteria. These findings show that the signaling pathway controlling root nodule organogenesis is mediated by SYMRK phosphorylation, which may help when engineering this trait into non-legume plants.
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Registered trials
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