ReviewJournal of Parkinson's disease2024
Identifying Subtle Motor Deficits Before Parkinson's Disease is Diagnosed: What to Look for?
Review in Journal of Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Development and clinical translation of smartphone-based digital biomarkers for Parkinson's disease: a structured review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Daily-Life, Sensor-Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease.Annals of neurology · 2026Article
- Bridging the global Parkinson's divide: Technology as a structural solution for equitable and brain health-integrated care.Journal of Parkinson's disease · 2026Review
- Spatio-temporal gait signatures across prodromal and early Parkinson's disease in two independent cohorts.Scientific reports · 2026Article
- Toward future diagnostics of Parkinson's disease: a perspective on multimodal motor assessment and personalized digital twins.Frontiers in aging neuroscience · 2026Article
- Turning Slowly Predicts Future Diagnosis of Parkinson's Disease: A Decade-Long Longitudinal Analysis.Annals of neurology · 2026Article
- Analyzing the 'Bradykinesia Complex' in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Parkinson's disease severity clustering based on gait activity from mobile device.Scientific reports · 2025Article
- Incidence of hip fractures in persons with and without Parkinson's disease in Finland: a 15-year longitudinal study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Video analysis reveals early signs of Bradykinesia in REM sleep behavior disorder and Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Enterococcus faecalis Exerts Neuroprotective Effects via the Vagus Nerve in a Mouse Model of Parkinson's Disease.Molecular neurobiology · 2025Article
- The diagnostic pathway of Parkinson's disease: understanding patient perspectives in Australia.NPJ Parkinson's disease · 2025Article
- Quantifying arm swing in Parkinson's disease: a method accounting for arm activities during free-living gait.Journal of neuroengineering and rehabilitation · 2025Article
- A framework to standardize gait study protocols in Parkinson's disease.Journal of Parkinson's disease · 2025Article
- Predictive potential of circular walking in prodromal Parkinson's disease.Journal of Parkinson's disease · 2025Article
- Tracking prodromal Parkinson's disease: a five-year follow-up of the PARCAS cohort.Frontiers in neurology · 2025Article
- Turning alterations detected by mobile health technology in idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2024Article
- Exercise for People with Parkinson's Disease: Updates and Future Considerations.Physical therapy research · 2024Review
- Introduction: The Earliest Phase of Parkinson's Disease: Possibilities for Detection and Intervention.Journal of Parkinson's disease · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor deficits typical of Parkinson's disease (PD), such as gait and balance disturbances, tremor, reduced arm swing and finger movement, and voice and breathing changes, are believed to manifest several years prior to clinical diagnosis. Here we describe the evidence for the presence and progression of motor deficits in this pre-diagnostic phase in order to provide suggestions for the design of future observational studies for an effective, quantitatively oriented investigation. On the one hand, these future studies must detect these motor deficits in as large (potentially, population-based) cohorts as possible with high sensitivity and specificity. On the other hand, they must describe the progression of these motor deficits in the pre-diagnostic phase as accurately as possible, to support the testing of the effect of pharmacological and non-pharmacological interventions. Digital technologies and artificial intelligence can substantially accelerate this process.
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Registered trials
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