Evidence map›Paper›PMID 38363583›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Exercise-induced cardiac troponin release in athletes with versus without coronary atherosclerosis.

Sylvan L J E Janssen, Femke de Vries, Alma M A Mingels, Geert Kleinnibbelink, Maria T E Hopman, Arend Mosterd, Birgitta K Velthuis, Vincent L Aengevaeren, Thijs M H Eijsvogels

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07625488 (Measuring Athlete's Risk of Cardiovascular Events 3), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07625488 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)

TypeobservationalSponsorRadboud University Medical CenterRan2026 to 2027Enrolled250ConditionsCoronary Artery Disease, Atherosclerosis
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sylvan L J E JanssenDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-3950-0523
Femke de VriesDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-4281-0779
Alma M A MingelsDepartment of Clinical Chemistry, Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.
Geert KleinnibbelinkDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-8364-2572
Maria T E HopmanDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Arend MosterdDepartment of Cardiology, Meander Medical Center, Amersfoort, The Netherlands.ORCID 0000-0002-6906-2643
Birgitta K VelthuisDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-2542-9474
Vincent L AengevaerenDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-8722-6739
Thijs M H EijsvogelsDepartment of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-0747-4471
Radboud University Nijmegen · NLMaastricht University · NLMeander Medisch Centrum · NLUniversity Medical Center Utrecht · NL

Funding

Dutch Research Council file number 09150161810155
6 · The paper itself

Abstract

The magnitude of exercise-induced cardiac troponin (cTn) elevations is dependent on cardiovascular health status, and previous studies have shown that occult coronary atherosclerosis is highly prevalent among amateur athletes. We tested the hypothesis that middle-aged and older athletes with coronary atherosclerosis demonstrate greater cTn elevations following a controlled endurance exercise test compared with healthy peers. We included 59 male athletes from the Measuring Athletes' Risk of Cardiovascular events 2 (MARC-2) study and stratified them as controls [coronary artery calcium score (CACS) = 0,

Indexed as

Coronary Artery DiseaseAgedAthletesBiomarkersConstriction, PathologicHumansMaleMiddle AgedTroponin ITroponin TBiomarkersTroponin ITroponin Tbiomarkerscardiologycardiovascular diseasescoronary artery diseaseheart diseases

Identifiers

PMID38363583
PMCPMC11279743
OpenAlexW4391885309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.