ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2024
Heterotopic ossification, osteolysis and implant failure following cervical total disc replacement with the M6-C™ artificial disc.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- Explant analysis of two rhine cervical discs.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Clinical outcome 24 months after cervical disc arthroplasty with a new articulating and viscoelastic disc prosthesis.Journal of spine surgery (Hong Kong) · 2026Article
- Complication Profiles Leading to Revision Surgery After Cervical Disc Arthroplasty.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2026Article
- A Commentary on "A Comprehensive Review of Spinal Arthroplasty".Neurospine · 2026Article
- The Total Disc Replacement Osteolysis Grading Scale - a simple, reliable and quantifiable tool for assessing, managing and reporting osteolysis after cervical total disc replacement.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- A Comprehensive Review of Spinal Arthroplasty.Neurospine · 2026Review
- Beyond the two-year trial: real-World failure mechanisms of the simplify cervical disc.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Rates of Osteolysis for Commercially Available Cervical Disc Arthroplasty Devices in the United States: A Manufacturer and User Facility Device Experience Database Analysis.International journal of spine surgery · 2025Article
- Historical trends and future projections of cervical disc arthroplasty and removal cervical disc arthroplasty in the United States Medicare population.North American Spine Society journal · 2025Article
- Patient outcomes and surgical strategies in revision cervical arthroplasty following M6-C™ disc-related osteolysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- The Future of Arthroplasty in the Spine.International journal of spine surgery · 2025Article
- Hidden blood loss and risk factors in percutaneous endoscopic cervical discectomy.Joint diseases and related surgery · 2025Article
- [Cervical disc herniation : Symptomatology, diagnostics, therapy].Orthopadie (Heidelberg, Germany) · 2025Review
- Adverse events associated with the Barricaid annular closure device: An analysis of the FDA MAUDE Database.Journal of craniovertebral junction & spineArticle
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA recent study reported a 34% mid-term revision rate after M6-C™ cervical total disc replacement (CTDR) for wear-related osteolysis. Here, we aim to investigate the prevalence, risk factors, and radiographic characteristics of periprosthetic bony changes and implant failure of the M6-C™ artificial disc.
methodsWe retrospectively analysed radiographic (conventional X-ray, CT scan) and clinical outcomes (EQ-5D-5L, Neck Disability Index (NDI), and Visual Analog Scale (VAS) for neck and arm pain) data collected during routine follow-up of patients who underwent CTDR with the M6-C™ between 2011 and 2015.
resultsIn total, 85 patients underwent CTDR with the M6-C™. Follow-up data were available for 43 patients (54% female, mean age 44 years) with 50 implants and a mean follow-up of 8.1 years (6.5-11 years). Implant failure with the presence of severe osteolysis was identified in 5 (12%) patients who were all male (p = 0.016) and implanted at the C5/6 level (p = 0.11). All failed implants required revision surgery. The overall prevalence of osteolysis was 44% (22/50 implants) and 34% (17/50 implants) for significant heterotopic ossification. Patients with high-grade osteolysis showed higher VAS arm pain (p = 0.05) and lower EQ-5D-VAS health VAS (p = 0.03).
conclusionWe report a lower reoperation rate for failed M6-C™ implants than previously published, but confirmed that osteolysis and heterotopic ossification are common following CTDR with the M6-C™ and may be asymptomatic. Therefore, we strongly recommend ongoing clinical and radiographic monitoring after CTDR with the M6-C™, particularly for male patients implanted at the C5/6 level.
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