Evidence map›Paper›PMID 38362881›Full record

ReviewVirulence2024

Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19.

Natalie M Kirk, Yuying Liang, Hinh Ly

Abstract readReview
In one paragraph

Review in Virulence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalie M KirkDepartment of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA.
Yuying LiangDepartment of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA.
Hinh LyDepartment of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA.ORCID 0000-0001-8271-2033

Funding

Comparative Medicine and Pathology TrainingT32OD010993 · OD · UNIVERSITY OF MINNESOTA · PI DAVID R BROWN, Cathy S. Carlson · 2012 to 2026
$6.2M
Viral Vectored COVID-19 Vaccines in a Guinea Pig Perinatal Infection ModelR21AI158019 · NIAID · UNIVERSITY OF MINNESOTA · PI LIANG, YUYING, SCHLEISS, MARK R. · 2022 to 2023
$426k
NIAID NIH HHS R21 AI158019NIH HHS T32 OD010993
6 · The paper itself

Abstract

Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.

Indexed as

COVID-19AnimalsDisease Models, AnimalHumansSARS-CoV-2Virulenceanimal modelscoronavirusespathogenesispathologyRespiratory pathogens

Identifiers

PMID38362881
PMCPMC10878030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.