Evidence map›Paper›PMID 38362707›Full record

ArticleRenal failure2024

Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway.

Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lemei HuDepartment of Nephrology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, PRChina.
Changqing ZhengSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, PRChina.
Ying KongSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, PRChina.
Zhiqing LuoSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, PRChina.
Fengzhang HuangDepartment of Nephrology, Guangzhou First People's Hospital, Guangzhou, PRChina.
Zhigang ZhuDepartment of Geriatrics, Division of Hematology and Oncology, Second Affiliated Hospital, Guangzhou First People's Hospital, College of Medicine, South China University of Technology, Guangzhou, PRChina.
Quhuan LiSchool of Bioscience and Bioengineering, South China University of Technology, Guangzhou, PR China.
Ming LiangDepartment of Nephrology, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, PRChina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArteriovenous fistula (AVF) is currently the preferred vascular access for hemodialysis patients. However, the low maturation rate of AVF severely affects its use in patients. A more comprehensive understanding and study of the mechanisms of AVF maturation is urgently needed. METHODS AND

resultsIn this study, we downloaded the publicly available datasets (GSE119296 and GSE220796) from the Gene Expression Omnibus (GEO) and merged them for subsequent analysis. We screened 84 differentially expressed genes (DEGs) and performed the functional enrichment analysis. Next, we integrated the results obtained from the degree algorithm provided by the Cytohubba plug-in, Molecular complex detection (MCODE) plug-in, weighted gene correlation network analysis (WGCNA), and Least absolute shrinkage and selection operator (LASSO) logistic regression. This integration allowed us to identify

conclusionsCTSG may promote AVF maturation by stimulating the secretion of MMP2 and MMP9 from VSMCs and reducing the extent of medial fibrosis in AVF veins by inhibiting the secretion of collagen I and collagen III.

Indexed as

Arteriovenous FistulaArteriovenous Shunt, SurgicalCathepsin GCollagenCollagen Type IHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9Renal DialysisCathepsin GCollagenCollagen Type IMatrix Metalloproteinase 2Matrix Metalloproteinase 9MMP2 protein, humanMMP9 protein, humanarteriovenous fistulaBioinformatic analysisCTSGnon-maturationvascular smooth muscle cells

Identifiers

PMID38362707
PMCPMC10878333

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.