ArticleHarvard data science review2020
Learning Lessons on Reproducibility and Replicability in Large Scale Genome-Wide Association Studies.
Article in Harvard data science review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- PROVGEN: A Privacy-Preserving Approach for Outcome Validation in Genomic Research.Proceedings on Privacy Enhancing Technologies. Privacy Enhancing Technologies Symposium · 2026Article
- Genomic selection and reproducibility: are complex models distracting us from true scientific validity in the presence of genotype-by-environment interaction?G3 (Bethesda, Md.) · 2025Article
- The reliability of replications: a study in computational reproductions.Royal Society open science · 2025Article
- Reproducibility and replicability in research: What 452 professors think in Universities across the USA and India.PloS one · 2025Article
- Assessing computational reproducibility in Behavior Research Methods.Behavior research methods · 2024Article
- Omics-based biomarkers as useful tools in metabolic dysfunction-associated steatotic liver disease clinical practice: How far are we?World journal of gastroenterology · 2024Review
- Article
- Open Science Practices in Psychiatric Genetics: A Primer.Biological psychiatry global open science · 2024Review
- Social determinants of health derived from people with opioid use disorder: Improving data collection, integration and use with cross-domain collaboration and reproducible, data-centric, notebook-style workflows.Frontiers in medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Reproducibility and replicability play a pivotal role in science. The article reflects on reproducibility and replicability as they figure in large scale genome-wide association studies. Overall, we emphasize the importance of enhancing data reproducibility, analysis reproducibility, and result replicability. We make recommendations pertaining to the development of study designs that address 1) batch effects and selection bias, 2) the incorporation of discrete discovery and replication phases, and 3) the procurement of a large sample size. We emphasize the importance of systematic and transparent data generation, processing, and quality control pipelines, as well as a rigorous field-specific standardized analysis protocol, We offer guidance with respect to collaborative frameworks, open access analysis tools, and software, and the use of supporting mandates, infrastructure, and repositories for data and resource sharing. Finally, we identify the role of incentives and culture in fueling the production of reproducible and replicable research through partnerships of researchers, funding agencies, and journals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.