Evidence map›Paper›PMID 38362501›Full record

ArticleFrontiers in microbiology2024

Combinations of the azaquinazoline anti-

Shrilakshmi Hegde, Amy E Marriott, Nicolas Pionnier, Andrew Steven, Christina Bulman, Emma Gunderson, Ian Vogel, Marianne Koschel, Alexandra Ehrens, Sara Lustigman and 13 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Detection ofTransboundary and emerging diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 4 countries.

Shrilakshmi HegdeDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Amy E MarriottDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Nicolas PionnierDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Andrew StevenDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Christina BulmanDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, Unites States.
Emma GundersonDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, Unites States.
Ian VogelDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, Unites States.
Marianne KoschelDepartment of Immunology and Parasitology, Institute for Medical Microbiology, University Hospital Bonn, Bonn, Germany.
Alexandra EhrensDepartment of Immunology and Parasitology, Institute for Medical Microbiology, University Hospital Bonn, Bonn, Germany.
Sara LustigmanLaboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, Unites States.
Denis VoroninLaboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, Unites States.
Nancy TricocheLaboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, Unites States.
Achim HoeraufDepartment of Immunology and Parasitology, Institute for Medical Microbiology, University Hospital Bonn, Bonn, Germany.
Marc P HübnerDepartment of Immunology and Parasitology, Institute for Medical Microbiology, University Hospital Bonn, Bonn, Germany.
Judy SakanariDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, Unites States.
Ghaith AljayyoussiDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Fabian GusovskyEisai Co., Ltd., Tokyo, Japan.
Jessica DagleyDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
David W HongDepartment of Chemistry, University of Liverpool, Liverpool, United Kingdom.
Paul O'NeillDepartment of Chemistry, University of Liverpool, Liverpool, United Kingdom.
Steven A WardDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Mark J TaylorDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Joseph D TurnerDepartment of Tropical Disease Biology, Centre for Drugs and Diagnostics, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Liverpool School of Tropical Medicine · GBUniversity of California, San Francisco · USNew York Blood Center · USGerman Center for Infection Research · DEUniversity Hospital Bonn · DEUniversity of Liverpool · GBEisai (Japan) · JP

Funding

Host-pathogen interactions in filarial worm infectionsZIAAI001322 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GHEDIN, ELODIE · 2020 to 2025
$6.7M
Medical Research Council MC_PC_18055Medical Research Council MC_PC_19045Medical Research Council MR/R025401/1Wellcome Trust
6 · The paper itself

Abstract

Lymphatic filariasis and onchocerciasis are two major neglected tropical diseases that are responsible for causing severe disability in 50 million people worldwide, whilst veterinary filariasis (heartworm) is a potentially lethal parasitic infection of companion animals. There is an urgent need for safe, short-course curative (macrofilaricidal) drugs to eliminate these debilitating parasite infections. We investigated combination treatments of the novel anti-

Indexed as

anti-Wolbachia drugsAWZ1066Sbenzimidazolelymphatic filariasismacrofilaricidal drugsonchocerciasisWolbachia

Identifiers

PMID38362501
PMCPMC10867176
OpenAlexW4391445401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.