ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology1985
Intracellular pH in hibernation and respiratory acidosis in the European hamster.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 57 citations in OpenAlex.
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- Changes in COJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Turn it off and on again: characteristics and control of torpor.Wellcome open research · 2021Review
- Regulation of blood oxygen transport in hibernating mammals.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Reassessment of the cold-labile nature of phosphofructokinase from a hibernating ground squirrel.Molecular and cellular biochemistry · 2001Article
- Effectors of metabolic depression in an estivating pulmonate snail (Helix aspersa): whole animal and in vitro tissue studies.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 1996Article
- Intracellular pH during daily torpor in Peromyscus maniculatus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 1990Article
- Time-course of blood acid-base state during arousal from hibernation in the European hamster.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 1988Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular pH was determined (DMO method) in European hamsters, in the spontaneously-occurring respiratory acidosis of hibernation, in hypercapnia due to breathing 12% CO2 in air in euthermy in spring, and in euthermicnormocapnic controls. From euthermy to hibernation, the temperature coefficient of pH was lowest in blood plasma and brain, intermediate in striated muscles (thigh muscles and diaphragm), and highest in heart and liver (Fig. 1). Correspondingly, the estimated dissociation ratio of the protein imidazole buffer groups, alpha Im, decreased markedly in plasma and brain, denoting an acid titration, but varied little in liver and heart. Striated muscles were intermediate (Fig. 2). Like in other mammals, intracellular responses to short-term euthermic respiratory acidosis were characterized by a partial metabolic compensation in the brain and a small metabolic acidification in striated muscles. In hibernation, a powerful metabolic compensation took place in liver and heart, nearly restoring alpha Im, but none occurred in brain (Figs. 3 to 5). The existence of an intracellular acidosis in brain and striated muscles during hibernation is in keeping with an inhibitory role of acidosis, whereas the homeostasis of intracellular alpha Im in liver and heart would subserve the eurythermal functioning of metabolic regulations in these organs, like in most organs of ectotherms.
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