Evidence map›Paper›PMID 38362305›Full record

ArticleEngineered regeneration2022

Structural and biomechanical characterizations of acellular porcine mitral valve scaffolds: anterior leaflets, posterior leaflets, and chordae tendineae.

Bo Wang, Leslie N Sierad, Jeremy J Mercuri, Agneta Simionescu, Dan T Simionescu, Lakiesha N Williams, Ryan Vela, Pietro Bajona, Matthias Peltz, Sharan Ramaswamy and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Engineered regeneration, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Bo WangJoint Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, Milwaukee, WI 53226, United States.
Leslie N SieradDepartment of Bioengineering, Clemson University, Clemson, SC 29634, United States.
Jeremy J MercuriDepartment of Bioengineering, Clemson University, Clemson, SC 29634, United States.
Agneta SimionescuDepartment of Bioengineering, Clemson University, Clemson, SC 29634, United States.
Dan T SimionescuDepartment of Bioengineering, Clemson University, Clemson, SC 29634, United States.
Lakiesha N WilliamsDepartment of Biomedical Engineering, University of Florida, Gainesville, FL 32611, United States.
Ryan VelaDepartment of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Pietro BajonaDepartment of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Matthias PeltzDepartment of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Sharan RamaswamyDepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, United States.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76010, United States.
Jun LiaoDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76010, United States.
Clemson University · USThe University of Texas at Arlington · USThe University of Texas Southwestern Medical Center · USAllegheny Health Network · USFlorida International University · USMarquette University · USUniversity of Florida · US

Funding

Cell and matrix interactions in diabetic vascular tissue engineering modelsR01HL133303 · NHLBI · CLEMSON UNIVERSITY · PI SIMIONESCU, AGNETA · 2018 to 2021
$1.4M
Bioactive injectable blends for cardiac stem cell recruitmentR15HL140503 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI HONG, YI · 2018 to 2018
$460k
A Controlled Septal Ablation for Inoperable Hypertrophic CardiomyopathyR15HL159599 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI LIAO, JUN · 2022 to 2022
$433k
NHLBI NIH HHS R01 HL133303NHLBI NIH HHS R15 HL140503NHLBI NIH HHS R15 HL159599
6 · The paper itself

Abstract

Mitral valve (MV) tissue engineering is still in its early stage, and one major challenge in MV tissue engineering is to identify appropriate scaffold materials. With the potential of acellular MV scaffolds being demonstrated recently, it is important to have a full understanding of the biomechanics of the native MV components and their acellular scaffolds. In this study, we have successfully characterized the structural and mechanical properties of porcine MV components, including anterior leaflet (AL), posterior leaflet (PL), strut chordae, and basal chordae, before and after decellularization. Quantitative DNA assay showed more than 90% reduction in DNA content, and

Indexed as

Chordae tendineaeDecellularizationHeart valve biomechanicsMitral valve tissue engineeringValve leaflets

Identifiers

PMID38362305
PMCPMC10869114
OpenAlexW4292979524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.