ArticleLaryngoscope investigative otolaryngology2024
Ossicular joint histopathology in cases of age-related hearing loss.
Article in Laryngoscope investigative otolaryngology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- The Transmission of Sound to the Cochlea in Normal and Pathological Human Middle Ears.Journal of the Association for Research in Otolaryngology : JARO · 2025Review
- Ossicular joint histopathology in cases of age-related hearing loss.Laryngoscope investigative otolaryngology · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Objectives: Age-related hearing loss (presbycusis) is a prevalent condition traditionally attributed to inner ear dysfunction. Little is known about age-related changes in the ossicular joints or their contribution to presbycusis. Herein, we performed an otopathologic evaluation of the ossicular joints in cases of presbycusis without a clear sensorineural explanation. Methods: Histopathologic analysis of the incudomallear (IM) and incudostapedial (IS) joints was performed in specimens from the National Temporal Bone Registry with audiometrically confirmed presbycusis but without histologically observed sensorineural, strial, or mixed features; deemed cases of "indeterminate" presbycusis. Specimens identified as "indeterminate" presbycusis (IP, Results: The synovial space at the center of the IM joint was wider in the IP group (194 ± 36.8 μm) compared to age-matched controls (138 ± 36.5 μm), young controls (149 ± 32.2 μm), and ears with sensorineural presbycusis (148 ± 52.7 μm) ( Conclusion: IP ears have wider IM and IS joints when compared to ears with sensorineural presbycusis and age-matched controls. Findings point to a potential middle ear source of high frequency conductive hearing loss in a subset of presbycutic ears. Level of Evidence: Retrospective study.
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