Evidence map›Paper›PMID 38362098›Full record

ArticleSaudi journal of medicine & medical sciences

The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway.

Sabah Ali Alzahrani, Gamal M Bekhet, Rebai Ben Ammar, Basem M Abdallah, Enas Mohamed Ali, Saeed Y Al-Ramadan, Duaa Althumairy, Peramaiyan Rajendran

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of medicine & medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 4 countries.

Sabah Ali AlzahraniDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Gamal M BekhetDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Rebai Ben AmmarDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Basem M AbdallahDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Enas Mohamed AliDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Saeed Y Al-RamadanDepartment of Anatomy, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Duaa AlthumairyDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Peramaiyan RajendranDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
King Faisal University · SACenter of Biotechnogy of Borj Cédria · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatotoxicity caused by CCL Objective: To investigate whether GNL could protect against oxidative stress induced by CCL Materials and Methods: Forty-eight female albino mice weighing 25-30 g were randomly allocated to 4 groups: Group I served as a control; Group II received a toxicity-inducing single dose of 15 μL of CCL Results: CCL Conclusion: GNL demonstrates a protective effect against CCl4-induced hepatorenal toxicity, mediated through the activation of the PI3K/AKT signaling pathway and the upregulation of Nrf2. These findings highlight the potential therapeutic implications of GNL in mitigating oxidative stress and inflammation in liver and kidney tissues.

Indexed as

Carbon tetrachloridegeranioloxidative stressphosphoinositide 3-kinases/protein kinase Bpregnant

Identifiers

PMID38362098
PMCPMC10866391
OpenAlexW4391018032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.