ArticleNature cardiovascular research2024
Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.
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Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
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Who cites it
30 citing papers in PubMed, 37 citations in OpenAlex.
- Salvianolic Acid a Disrupts the HSP90α-AKT-PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gaseous Air Pollutant Exposure and Atherosclerosis: A Systematic Study Integrating Multi-Omics and Network Toxicology.International journal of molecular sciences · 2026Article
- Multimodal profiling of pro-inflammatory protease activity identifies caspase-1 as a target for lung cancer interception.Science advances · 2026Article
- IL-1-Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis.JACC. Basic to translational science · 2026Article
- Article
- Unraveling Atherosclerosis through Multi-omics: Systematic Insights into the Unique Applications and Clinical Perspectives.Current atherosclerosis reports · 2026Review
- Genetic factors contributing to atherosclerosis.Current opinion in cardiology · 2026Review
- Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2JACC. Basic to translational science · 2026Article
- Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2Journal of lipid research · 2026Article
- Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease.European heart journal · 2026Article
- Molecular basis of coronary artery disease-malignancy comorbidity: inflammation, immunometabolism, thrombosis, and cardio-oncology translation.Frontiers in immunology · 2026Review
- Pathological mechanisms of inflammatory responses in atherosclerosis and the multi-target regulatory effects of traditional Chinese medicine.Frontiers in cardiovascular medicine · 2026Review
- Increased Local Expression of Interleukin-1β in Patients with Acute Myocardial Infarction with Local Layered Plaque.Journal of inflammation research · 2026Article
- Research progress on targeted regulatory proteins in the prevention and treatment of atherosclerosis.Frontiers in immunology · 2026Review
- Three-Dimensional Perspectives on Inflammatory Regulation in Coronary Atherosclerosis: Integrated Mechanisms of Endothelial Priming, Lipid Metabolism, and Cytokine Synergy.Reviews in cardiovascular medicine · 2026Review
- Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries.Nature communications · 2025Article
- Smooth muscle cells in atherosclerosis: essential but overlooked translational perspectives.European heart journal · 2025Review
- Target practice: Opportunities for therapeutic intervention in CHIP and CCUS.Blood reviews · 2025Review
- PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition.Nature cardiovascular research · 2025Article
- Applications and techniques of single-cell RNA sequencing across diverse species.Briefings in bioinformatics · 2025Review
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Authors and funding
15 authors at 6 institutions in 3 countries.
Trevor P FidlerDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-0758-9984
Andrew DunbarHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eunyoung KimDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-9749-9930
Brian HardawayDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Jessica PauliDepartment of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany.
Chenyi XueDepartment of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany.
Sandra AbramowiczDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Tong XiaoDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-1462-4650
Kavi O'ConnorHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0008-0830-3731
Nadja SachsDepartment of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany.
Nan WangDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-9976-0859
Lars MaegdefesselDepartment of Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany.ORCID 0000-0001-5228-2634
Ross LevineHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7884-1905
Muredach ReillyDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-3035-9386
Alan R TallDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-7708-2417
Columbia University Irving Medical Center · USMemorial Sloan Kettering Cancer Center · USGerman Centre for Cardiovascular Research · DEKarolinska Institutet · SETechnical University of Munich · DEUniversity of California, San Francisco · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MSynergistic role of signaling and epigenetics in leukemic transformationR35CA197594 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Ross L Levine · 2017 to 2026
$11.4MCholesterol efflux, CHIP and inflammasome activationR01HL107653 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2011 to 2026
$7.7MClonal hematopoiesis, inflammasomes and atherosclerosisR01HL155431 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2021 to 2026
$3.7MMechanisms of Atherogenesis in Clonal HematopoiesisR00HL157649 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FIDLER, TREVOR PERAWASKIN LARAMEE · 2023 to 2025
$747kNew therapeutic approaches in clonal hematopoiesis and atherosclerosisR01HL170157 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TALL, ALAN RICHARD · 2023 to 2023
$695kBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kBecton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413kMechanisms of Atherogenesis in Clonal HematopoiesisK99HL157649 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDLER, TREVOR PERAWASKIN LARAMEE · 2022 to 2023
$331kCardiovascular consequences of increased inflammasome activation in Jak2vf-mediated clonal hematopoiesisF32HL151051 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDLER, TREVOR PERAWASKIN LARAMEE · 2020 to 2020
$66kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA013696NCI NIH HHS R35 CA197594NCRR NIH HHS S10 RR027050NHLBI NIH HHS F32 HL151051NHLBI NIH HHS K99 HL157649NHLBI NIH HHS R00 HL157649NHLBI NIH HHS R01 HL107653NHLBI NIH HHS R01 HL155431NHLBI NIH HHS R01 HL170157NIH HHS S10 OD020056
Abstract
Clonal hematopoiesis (CH) is an independent risk factor for atherosclerotic cardiovascular disease. Murine models of CH suggest a central role of inflammasomes and IL-1β in accelerated atherosclerosis and plaque destabilization. Here we show using single-cell RNA sequencing in human carotid plaques that inflammasome components are enriched in macrophages, while the receptor for IL-1β is enriched in fibroblasts and smooth muscle cells (SMCs). To address the role of inflammatory crosstalk in features of plaque destabilization, we conducted SMC fate mapping in
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