Evidence map›Paper›PMID 38361583›Full record

ArticleFrontiers in cardiovascular medicine2024

Molecular effects of cardiac contractility modulation in patients with heart failure of ischemic aetiology uncovered by transcriptome analysis.

E Lyasnikova, K Sukhareva, M Vander, K Zaitsev, M Firulyova, A Sergushichev, M Sorokina, M Trukshina, V Galenko, T Lelyavina and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

E LyasnikovaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
K SukharevaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
M VanderInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
K ZaitsevComputer Technologies Laboratory, ITMO University, Saint Petersburg.
M FirulyovaComputer Technologies Laboratory, ITMO University, Saint Petersburg.
A SergushichevComputer Technologies Laboratory, ITMO University, Saint Petersburg.
M SorokinaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
M TrukshinaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
V GalenkoInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
T LelyavinaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
L MitrofanovaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
K SimonovaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
M AbramovInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
G FaggianGraduate School of Life and Health Science, University of Verona, Verona, Italy.
G B LucianiGraduate School of Life and Health Science, University of Verona, Verona, Italy.
D S LebedevInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
E N MikhaylovInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
M SitnikovaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
A KostarevaInstitute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Federal Almazov North-West Medical Research Centre · RUITMO University · RUUniversity of Verona · ITKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac contractility modulation (CCM) is based on electrical stimulation of the heart without alteration of action potential and mechanical activation, the data on its fundamental molecular mechanisms are limited. Here we demonstrate clinical and physiological effect of 12 months CCM in 29 patients along with transcriptomic molecular data. Based on the CCM effect the patients were divided into two groups: responders (

Indexed as

autophagyCCMheart failureoptimizerRNA sequencingsarcomeric genes

Identifiers

PMID38361583
PMCPMC10867213
OpenAlexW4391444304

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.