ArticleBrain and behavior2024
Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression.
Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Structural alterations in the superior temporal gyrus associated with depressive symptoms in migraine without aura: a voxel-based morphometry and surface-based morphometry magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Migraine and menopause as converging factors in brain vulnerability: a hypothesis-driven perspective.The journal of headache and pain · 2026Review
- Reduced emotion-generated frontolimbic functional connectivity in psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder.European child & adolescent psychiatry · 2026Article
- Functional Brain Connectivity Patterns of Headache-Mental Disorder Comorbidity in Patients With Migraine.CNS neuroscience & therapeutics · 2025Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Do headaches impact pregnancy planning behaviors? A cross-sectional school-based study in Japan.The journal of headache and pain · 2025Article
- Aberrant cerebral activity in patients with unruptured intracranial aneurysm: a resting-state functional MRI study.Brain structure & function · 2025Article
- Limbic system abnormalities in episodic cluster headache: a 7T MRI multimodal study.The journal of headache and pain · 2025Article
- Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression.Brain and behavior · 2024Article
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Authors and funding
5 authors.
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Abstract
objectiveThe comorbid relationship between migraine and depression has been well recognized, but its underlying pathophysiology is unclear. Here, we aimed to explore the structural changes of the amygdala and the abnormal functional connectivity of the centromedial amygdala (CMA) in migraineurs with depression.
methodsHigh-resolution T1-weighted and functional magnetic resonance images were acquired from 22 episodic migraineurs with comorbid depression (EMwD), 21 episodic migraineurs without depression (EM), and 17 healthy controls (HC). Voxel-based morphometry and resting-state functional connectivity (rsFC) were applied to examine the intergroup differences in amygdala volume.
resultsThe bilateral amygdala volume was increased in the EMwD and EM groups compared with the HC group, but there were no differences between the EMwD and EM groups. The right CMA exhibited decreased rsFC in the left dorsolateral prefrontal cortex (DLPFC) in the EMwD group compared with the EM group, while rsFC increased between the CMA and the contralateral DLPFC in the EM group compared with the HC group. In addition, the EM group showed decreased rsFC between the left CMA and the left pallidum compared with the HC group.
conclusionsEnlarged amygdala is an imaging feature of EM and EMwD. The inconsistency of rsFC between CMA and DLPFC between migraineurs with and without depression might indicate that decreased rsFC between CMA and DLPFC is a neuropathologic marker for the comorbidity of migraine and depression. The core regions might be a potential intervention target for the treatment of EMwD in the future.
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