Evidence map›Paper›PMID 38361316›Full record

ArticleBrain and behavior2024

SLC6A4 gene variants moderate associations between childhood food insecurity and adolescent mental health.

S Pilkay, M Nolasco, S Nunes, A Riffer, D Femia, D Halevy, T Veerman, S Heiland, N Suwannimit, N Trexler and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

S PilkayDavid B. Falk College of Sport and Human Dynamics, School of Social Work, Syracuse University, Syracuse, New York, USA.
M NolascoDavid B. Falk College of Sport and Human Dynamics, School of Social Work, Syracuse University, Syracuse, New York, USA.ORCID 0009-0005-7940-7966
S NunesDavid B. Falk College of Sport and Human Dynamics, School of Social Work, Syracuse University, Syracuse, New York, USA.
A RifferJane Addams College of Social Work, University of Illinois Chicago, Chicago, Illinois, USA.
D FemiaDavid B. Falk College of Sport and Human Dynamics, School of Social Work, Syracuse University, Syracuse, New York, USA.
D HalevyWurzweiler School of Social Work, Yeshiva University, New York, New York, USA.ORCID 0000-0001-6575-8355
T VeermanSchool of Natural Health, Social and Behavioral Sciences, Social Work, Centenary University, Hackettstown, New Jersey, USA.
S HeilandDavid B. Falk College of Sport and Human Dynamics, School of Social Work, Syracuse University, Syracuse, New York, USA.
N SuwannimitDavid B. Falk College of Sport and Human Dynamics, School of Social Work, Syracuse University, Syracuse, New York, USA.
N TrexlerDavid B. Falk College of Sport and Human Dynamics, School of Social Work, Syracuse University, Syracuse, New York, USA.
B GumpDavid B. Falk College of Sport and Human Dynamics, Department of Public Health, Syracuse University, Syracuse, New York, USA.
Syracuse University · USCentenary College of New Jersey · USUniversity of Illinois Urbana-Champaign · USYeshiva University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFood insecurity is a persistent concern in the United States and has been shown to affect child mental health and behavior. The SLC6A4 gene has been indicated as a moderator of the effects of chronic stress on anxiety in adolescents aged 14-21. However, it is unclear if SLC6A4 may also play a role in the effects of childhood food insecurity, a form of chronic stress, on adolescent mental health. This study aimed to identify effects of food insecurity on adolescents' mental health and delinquent behavior when both mom and child go hungry in the child's early years, and the potential interaction with SLC6A4 variants (SS/LL).

methodsThe data and sample for this research are from the Future of Families and Child Wellbeing Study. The cohort consists of 4898 children (age 1-15 years, male = 47%, African American = 50%) and their respective caregivers sampled from large cities in the United States from 1998 to 2000.

resultsThe SLC6A4 serotonin transporter short/short allele emerged statistically significant as a moderator of childhood food insecurity and adolescent mental health. Specifically, the presence of the short/short allele increased anxiety symptoms in adolescents with exposure to food insecurity in childhood.

conclusionThe SLC6A4 short/short allele amplifies risk of anxiety-related mental illness when children experience food insecurity. The gene-environment interaction provides insight into the mechanistic pathway of the effects of poverty-related adversity, such as food insecurity, on developmental trajectories of mental health.

Indexed as

Food InsecurityMental DisordersMental HealthSerotonin Plasma Membrane Transport ProteinsAdolescentChildHumansMalePovertyUnited StatesSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanadolescenceanxietyfood insecuritygene-environmentSLC6A4

Identifiers

PMID38361316
PMCPMC10869890
OpenAlexW4391886745

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.