Evidence map›Paper›PMID 38360903›Full record

ArticleNPJ Parkinson's disease2024

Distinctive CD56

Stephen Weber, Kelly B Menees, Jieun Park, Julian Agin-Liebes, Chih-Chun Lin, Roy N Alcalay, Jae-Kyung Lee

Open access · goldAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Natural killer cells in multiple sclerosis: foe or friends?Frontiers in cellular neuroscience · 2025
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stephen Weber *Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA, USA.
Kelly B Menees *Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA, USA.ORCID http://orcid.org/0000-0003-4282-8546
Jieun ParkHarrison College of Pharmacy, Auburn University, Auburn, AL, USA.ORCID http://orcid.org/0000-0001-7980-9627
Julian Agin-LiebesDepartment of Neurology, Columbia University Medical Center, New York, NY, USA.
Chih-Chun LinDepartment of Neurology, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7602-8590
Roy N AlcalayDepartment of Neurology, Columbia University Medical Center, New York, NY, USA.
Jae-Kyung LeeDepartment of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA, USA. jamlee@uga.edu.ORCID http://orcid.org/0000-0003-0104-8623
Columbia University Irving Medical Center · USGeorgia College & State University · USAuburn University · US

Funding

Elucidating the role of NK cells in Lewy body diseasesR01NS119610 · NINDS · UNIVERSITY OF GEORGIA · PI LEE, JAE-KYUNG JAMISE · 2021 to 2025
$1.9M
NINDS NIH HHS R01 NS119610
6 · The paper itself

Abstract

Mounting data suggest an important role for the immune system in Parkinson's disease (PD). Previous evidence of increased natural killer (NK) cell populations in PD suggests a potential role of NK cells in the pathogenesis of the disease. Previous studies have analyzed NK cell populations using aggregation by variable expression of CD56 and CD16. It remains unknown what differences may exist between NK cell subpopulations when stratified using more nuanced classification. Here, we profile NK cell subpopulations and elucidate the expressions of activating, NKG2D, inhibitory, NKG2A, and homing, CX3CR1, receptors on NK cell subpopulations in PD and healthy controls (HC). We analyzed cryopreserved PMBC samples using a 10-color flow cytometry panel to evaluate NK cell subpopulations in 31 individuals with sporadic PD and 27 HC participants. Here we identified significant differences in the CD56

Identifiers

PMID38360903
PMCPMC10869354
OpenAlexW4391836293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.