ArticleLeukemia2024
Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children's Oncology Group Report.
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Article in Leukemia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Non-specific Clones Hamper the Reliability of Immunoglobulin Light Chain Gene Rearrangements in Next-Generation Sequencing-Based Measurable Residual Disease Monitoring in Pediatric B-Cell Acute Lymphoblastic Leukemia: A Single-Center Cohort Study.Annals of laboratory medicine · 2026Observational
- Hyperleukocytosis and outcomes in pediatric B-cell acute lymphoblastic leukemia: A report from the REDIAL Consortium.medRxiv : the preprint server for health sciences · 2026Article
- An international framework for clinical translation of molecular classifiers in osteosarcoma.NPJ precision oncology · 2026Article
- [Recent advances in individualized treatment for pediatric high-risk B-cell acute lymphoblastic leukemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- The GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer.iScience · 2026Article
- Clinical evidence and biological mechanisms linking obesity to adverse outcomes in pediatric and adolescent acute lymphoblastic leukemia.Frontiers in oncology · 2026Review
- AutoML identification of microRNA biomarkers in high-risk pediatric acute lymphoblastic leukemia.Non-coding RNA research · 2025Article
- Early detection and better outcomes: molecular approaches in pediatric hematologic malignancies - a review.Annals of medicine and surgery (2012) · 2025Review
- Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia.Blood cancer discovery · 2025Article
- Association ofCurrent issues in molecular biology · 2025Article
- Mortality after cancer diagnosis among children with congenital heart disease in Denmark and Sweden.Journal of the National Cancer Institute · 2025Article
- Review
- Real time-PCR a diagnostic tool for reporting copy number variation and relative gene-expression changes in pediatric B-cell acute lymphoblastic leukemia-a pilot study.Biology methods & protocols · 2025Article
- Article
- Association of Vitamin A and D Deficiencies with Infectious Outcomes in Children Undergoing Intensive Induction Therapy for Acute Lymphoblastic Leukemia.The Journal of pediatrics · 2024Article
- Exploring the potential of IL-10 for risk assessment and early intervention in pediatric ALL.BMC cancer · 2024Article
Corrections and comments
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Authors and funding
31 authors at 20 institutions in 2 countries.
N J DelRoccoDepartment of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL, USA. delrocco@usc.edu.ORCID 0000-0002-8139-9839
M L LohDepartment of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4099-4700
M J BorowitzDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
S GuptaDivision of Haematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
K R RabinDivision of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4081-8195
P Zweidler-McKayImmunogen, Inc, Waltham, MA, USA.
K W MaloneyDepartment of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora, CO, USA.
L A MattanoHARP Pharma Consulting, Mystic, CT, USA.ORCID 0000-0002-8409-0589
E LarsenDepartment of Pediatrics, Maine Children's Cancer Program, Scarborough, ME, USA.
A AngiolilloServier Pharmaceuticals, Boston, MA, USA.
R J SchoreDivision of Pediatric Oncology, Children's National Hospital, Washington, DC and the George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0002-1582-2168
M J BurkeDivision of Pediatric Hematology-Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-6626-2773
W L SalzerUniformed Services University, F. Edward Hebert School of Medicine, Bethesda, MD, USA.
B L WoodChildren's Hospital Los Angeles, Pathology and Laboratory Medicine, Los Angeles, CA, USA.
A J CarrollDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-9844-730X
N A HeeremaDepartment of Pathology, The Ohio State University Wexner School of Medicine, Columbus, OH, USA.
S C ReshmiDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital and Departments of Pathology and Pediatrics, Ohio State University College of Medicine, Columbus, OH, USA.
J M Gastier-FosterDepartment of Pathology, The Ohio State University Wexner School of Medicine, Columbus, OH, USA.
R HarveyUniversity of New Mexico Cancer Center, Albuquerque, NM, USA.
I M ChenUniversity of New Mexico Cancer Center, Albuquerque, NM, USA.
K G RobertsDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7626-4043
C G MullighanDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1871-1850
C WillmanMayo Clinic, Cancer Center/Laboratory Medicine and Pathology, Rochester, NY, USA.
N WinickUTSouthwestern, Simmons Cancer Center, Dallas, TX, USA.ORCID 0000-0002-6636-3870
W L CarrollPerlmutter Cancer Center and Department of Pediatrics, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-1550-4167
R E RauDepartment of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
D T TeacheyDepartment of Pediatrics and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7373-8987
S P HungerDepartment of Pediatrics and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.
E A RaetzPerlmutter Cancer Center and Department of Pediatrics, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-8547-1658
M DevidasDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1099-3478
J A KairallaDepartment of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
St. Jude Children's Research Hospital · USBaylor College of Medicine · USChildren's Hospital of Philadelphia · USNYU Langone Health · USSeattle Children's Hospital · USUniversity of New Mexico · USChildren's Hospital Colorado · USChildren's Hospital of Los Angeles · USGeorge Washington University · USImmunoGen (United States) · USJohns Hopkins University · USMayo Clinic · USMedical College of Wisconsin · USNationwide Children's Hospital · USNew England Cancer Specialists · USThe Ohio State University Wexner Medical Center · USThe University of Texas Southwestern Medical Center · USUniformed Services University of the Health Sciences · USUniversity of Alabama at Birmingham · USUniversity of Florida · US
Funding
NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MCOG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5MCOG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8MChildren's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DEVIDAS, MEENAKSHI · 2003 to 2013
$67.5MCOG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5MSupport for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5MTranslating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4MNCI NIH HHS R35 CA197695NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA114766NCI NIH HHS U24 CA196173
Abstract
Current strategies to treat pediatric acute lymphoblastic leukemia rely on risk stratification algorithms using categorical data. We investigated whether using continuous variables assigned different weights would improve risk stratification. We developed and validated a multivariable Cox model for relapse-free survival (RFS) using information from 21199 patients. We constructed risk groups by identifying cutoffs of the COG Prognostic Index (PI
Indexed as
Burkitt LymphomaPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor Cell Lymphoblastic Leukemia-LymphomaChildDisease-Free SurvivalHumansPrognosisRecurrenceRisk AssessmentYoung Adult
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.