Evidence map›Paper›PMID 38360653›Full record

ArticleBMC cancer2024

The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma.

Alhadi Almangush, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Ricardo D Coletta, Antti A Mäkitie, Tuula Salo, Ilmo Leivo

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Alhadi AlmangushDepartment of Pathology, University of Helsinki, FI-00014, Helsinki, Haartmaninkatu, P.O. Box 21, Finland. alhadi.almangush@helsinki.fi.
Jaana HagströmDepartment of Pathology, University of Helsinki, FI-00014, Helsinki, Haartmaninkatu, P.O. Box 21, Finland.
Caj HaglundResearch Programs Unit, Translational Cancer Medicine, University of Helsinki, 00014, Helsinki, P.O. Box 63, Finland.
Luiz Paulo KowalskiDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, Department of Head and Neck Surgery, University of Sao Paulo Medical School, 05402-000, São Paulo, SP, Brazil.
Ricardo D ColettaDepartment of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, 13414-018, Piracicaba, São Paulo, Brazil.
Antti A MäkitieResearch Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tuula SaloDepartment of Pathology, University of Helsinki, FI-00014, Helsinki, Haartmaninkatu, P.O. Box 21, Finland.
Ilmo LeivoInstitute of Biomedicine, Pathology, University of Turku, Turku University Central Hospital, 20520, Turku, Finland.
University of Helsinki · FIAC Camargo Hospital · BRKarolinska Institutet · SETurku University Hospital · FIUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC).

methodsWe used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC.

resultsSingle cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224-3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080-2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216-3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067-2.538, P = 0.024).

conclusionSingle cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsTongue NeoplasmsHumansNeoplasm StagingPrognosisRetrospective StudiesSquamous Cell Carcinoma of Head and NeckEarly stageLarge nucleiOral tongue cancerSingle cell invasionSurvival

Identifiers

PMID38360653
PMCPMC10870554
OpenAlexW4391844922

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.