Evidence map›Paper›PMID 38360261›Full record

ArticleThe Journal of pediatrics2024

Relationship of Neonatal Seizure Burden Before Treatment and Response to Initial Antiseizure Medication.

Adam L Numis, Hannah C Glass, Bryan A Comstock, Fernando Gonzalez, Nathalie L Maitre, Shavonne L Massey, Dennis E Mayock, Ulrike Mietzsch, Niranjana Natarajan, Gregory M Sokol and 8 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02811263 (High-dose Erythropoietin for Asphyxia and Encephalopathy), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02811263 phase3completednot on this map

High-dose Erythropoietin for Asphyxia and Encephalopathy

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2022Enrolled500ConditionsNeonatal Encephalopathy, Birth AsphyxiaArmsNormal saline placebo, Erythropoietin
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Rethinking the definition of neonatal status epilepticus.European journal of pediatrics · 2025
    Review
  5. Article
  6. Article
  7. Status epilepticus in the neonate.BMJ paediatrics open · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Adam L NumisDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA; Department of Pediatrics UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA. Electronic address: Adam.numis@ucsf.edu.
Hannah C GlassDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA; Department of Pediatrics UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA.
Bryan A ComstockDepartment of Biostatistics, University of Washington, Seattle, WA.
Fernando GonzalezDepartment of Pediatrics UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
Nathalie L MaitreDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA.
Shavonne L MasseyDepartments of Neurology and Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Dennis E MayockDivision of Neonatology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.
Ulrike MietzschDivision of Neonatology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
Niranjana NatarajanDivision of Pediatric Neurology, Department of Neurology, University of Washington School of Medicine, Seattle, WA.
Gregory M SokolDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
Sonia BonifacioDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Krisa Van MeursDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Cameron ThomasDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Kaashif AhmadPediatrix Medical Group of San Antonio, Children's Hospital of San Antonio, San Antonio, TX.
Patrick HeagertyDepartment of Biostatistics, University of Washington, Seattle, WA.
Sandra E JuulDivision of Neonatology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.
Yvonne W WuDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA; Department of Pediatrics UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
Courtney J WusthoffDepartments of Neurology & Pediatrics, Stanford University, Stanford, CA.
University of Washington · USStanford University · USEmory University · USIndiana University – Purdue University Indianapolis · US

Funding

High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) DCCU01NS092553 · NINDS · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J · 2016 to 2020
$1.7M
HEAL - EEG - Neurophysiologic measures of Epo treatment for hypoxic-ischemic encephalopathy (HIE)R01NS104322 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY · 2018 to 2021
$1.5M
Evaluating the Role of Inflammation in Neonatal EpileptogenesisK23NS105918 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NUMIS, ADAM LAWRENCE · 2019 to 2023
$1.1M
A Multicenter Study of EEG in Premature Infants with Neonatal EncephalopathyK02NS102598 · NINDS · STANFORD UNIVERSITY · PI WUSTHOFF, COURTNEY JANE · 2017 to 2019
$606k
NINDS NIH HHS K02 NS102598NINDS NIH HHS K23 NS105918NINDS NIH HHS R01 NS104322NINDS NIH HHS U01 NS092553NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

objectiveTo assess among a cohort of neonates with hypoxic-ischemic encephalopathy (HIE) the association of pretreatment maximal hourly seizure burden and total seizure duration with successful response to initial antiseizure medication (ASM). STUDY

designThis was a retrospective review of data collected from infants enrolled in the HEAL Trial (NCT02811263) between January 25, 2017, and October 9, 2019. We evaluated a cohort of neonates born at ≥36 weeks of gestation with moderate-to-severe HIE who underwent continuous electroencephalogram monitoring and had acute symptomatic seizures. Poisson regression analyzed associations between (1) pretreatment maximal hourly seizure burden, (2) pretreatment total seizure duration, (3) time from first seizure to initial ASM, and (4) successful response to initial ASM.

resultsAmong 39 neonates meeting inclusion criteria, greater pretreatment maximal hourly seizure burden was associated with lower chance of successful response to initial ASM (adjusted relative risk for each 5-minute increase in seizure burden 0.83, 95% CI 0.69-0.99). There was no association between pretreatment total seizure duration and chance of successful response. Shorter time-to-treatment was paradoxically associated with lower chance of successful response to treatment, although this difference was small in magnitude (relative risk 1.007, 95% CI 1.003-1.010).

conclusionsMaximal seizure burden may be more important than other, more commonly used measures in predicting response to acute seizure treatments.

Indexed as

AnticonvulsantsElectroencephalographyHypoxia-Ischemia, BrainSeizuresFemaleHumansInfant, NewbornMaleRetrospective StudiesTreatment OutcomeAnticonvulsantsEEGerythropoietinhypoxic–ischemic encephalopathyneonatal encephalopathy

Identifiers

PMID38360261
PMCPMC13361129
OpenAlexW4391775418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.