Evidence map›Paper›PMID 38360052›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

First-in-Human Study of

Lindsey R Drake, Yanjun Wu, Mika Naganawa, Ruth Asch, Chao Zheng, Soheila Najafzadeh, Richard Pracitto, Marcel Lindemann, Songye Li, Jim Ropchan and 11 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Detection of Focal Lesions in Epilepsy with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Noninvasive Quantification of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Article
  4. Article
  5. SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  7. Review
  8. Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  9. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lindsey R DrakeYale PET Center, New Haven, Connecticut.
Yanjun WuYale PET Center, New Haven, Connecticut.
Mika NaganawaYale PET Center, New Haven, Connecticut.
Ruth AschYale PET Center, New Haven, Connecticut.
Chao ZhengYale PET Center, New Haven, Connecticut.
Soheila NajafzadehYale PET Center, New Haven, Connecticut.
Richard PracittoYale PET Center, New Haven, Connecticut.
Marcel LindemannYale PET Center, New Haven, Connecticut.
Songye LiYale PET Center, New Haven, Connecticut.
Jim RopchanYale PET Center, New Haven, Connecticut.
David LabareeYale PET Center, New Haven, Connecticut.
Paul R EmeryYale PET Center, New Haven, Connecticut.
Mark DiasYale PET Center, New Haven, Connecticut.
Shannan HenryYale PET Center, New Haven, Connecticut.
Nabeel NabulsiYale PET Center, New Haven, Connecticut.
David MatuskeyYale PET Center, New Haven, Connecticut.
Ansel T HillmerYale PET Center, New Haven, Connecticut.
Jean-Dominique GallezotYale PET Center, New Haven, Connecticut.
Richard E CarsonYale PET Center, New Haven, Connecticut.
Zhengxin CaiYale PET Center, New Haven, Connecticut henry.huang@yale.edu jason.cai@yale.edu.
Yiyun Huang

Funding

Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
SV2A PET in Spinal Cord Injury ImagingR01NS123183 · NINDS · YALE UNIVERSITY · PI Zhengxin Cai · 2022 to 2026
$3.3M
NCATS NIH HHS KL2 TR001862NINDS NIH HHS R01 NS123183
6 · The paper itself

Abstract

PET imaging of synaptic vesicle glycoprotein 2A allows for noninvasive quantification of synapses. This first-in-human study aimed to evaluate the kinetics, test-retest reproducibility, and extent of specific binding of a recently developed synaptic vesicle glycoprotein 2A PET ligand, (

Indexed as

18F-SynVesT-2brain PETdosimetryfirst-in-humankinetic modelingSV2A

Identifiers

PMID38360052
PMCPMC10924160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.