ArticleCell genomics2024
Quantitative and qualitative mutational impact of ionizing radiation on normal cells.
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Article in Cell genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
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- Loss of IGF-1R impairs DNA-PKcs recruitment to chromatin leading to defective end-joining.Molecular oncology · 2026Article
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- Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity.bioRxiv : the preprint server for biology · 2026Article
- Somatic mutations and clonal evolution in normal tissues and cancer development.Experimental & molecular medicine · 2026Review
- Microarray-Based Genomic Profiling in Low-Dose Radiation Research: Evidence, Limitations, and Translational Perspectives.International journal of molecular sciences · 2026Review
- A polymer physics model of the interphase cell nucleus for radiobiological simulations.Scientific reports · 2026Article
- Somatic mutation profiles in aged military nuclear test veterans: A comparative whole-genome sequence study.PloS one · 2026Article
- APOBEC3A drives deaminase mutagenesis in human gastric epithelium.Genome research · 2025Article
- Genomic landscape of radiation-induced somatic mutations in a normal cell.Carcinogenesis · 2025Review
- Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.Cell stem cell · 2025Article
- Mutagenic Impact and Evolutionary Influence of Chemoradiotherapy in Hematologic Malignancies.Blood cancer discovery · 2025Article
- Mutational Signatures in Radiation-Induced Cancer: A Review of Experimental Animal and Human Studies.Biology · 2025Review
- Distinctive molecular features of radiation-induced thyroid cancers.Science advances · 2025Article
- Trans-Scale Insights into Variability in Radiation Cancer Risk Across Tissues, Individuals, and Species.Biology · 2025Review
- Review
- Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
39 authors at 7 institutions in 5 countries.
Jeonghwan YoukGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Hyun Woo KwonDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Department of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Joonoh LimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA.
Eunji KimDepartment of Radiation Oncology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20, Boramae-ro 5 Gil, Dongjak-gu, Seoul 07061, Republic of Korea; Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Taewoo KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Ryul KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA.
Seongyeol ParkGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA.
Kijong YiGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA.
Chang Hyun NamGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Sara JeonDepartment of Biological Sciences & IMBG, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
Yohan AnGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Jinwook ChoiWellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, CB2 0AW Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3EL Cambridge, UK.
Hyelin NaInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Eon-Seok LeeResearch Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Youngwon ChoDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
Dong-Wook MinDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
HyoJin KimResearch Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Yeong-Rok KangResearch Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Si Ho ChoiResearch Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Min Ji BaeResearch Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Chang Geun LeeResearch Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Joon-Goon KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KI for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea.
Young Seo KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KI for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea.
Tosol YuDepartment of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiation Oncology, Dongnam Institute of Radiological and Medical Science, Busan 46033, Republic of Korea.
Won-Chul LeeGenome Insight, Inc., San Diego, CA 92121, USA.
Jong-Yeon ShinGenome Insight, Inc., San Diego, CA 92121, USA.
Dong Soo LeeDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Tae-You KimDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Taeyun KuGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KI for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea.
Su Yeon KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Joo-Hyeon LeeWellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, CB2 0AW Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3EL Cambridge, UK.
Bon-Kyoung KooInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Hyunsook LeeDepartment of Biological Sciences & IMBG, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
On Vox YiDepartment of Breast Surgery, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Eon Chul HanDepartment of Surgery, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea.
Ji Hyun ChangDepartment of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: jh.chang@snu.ac.kr.
Kyung Su KimDepartment of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: kskim.cirt@snu.ac.kr.
Tae Gen SonResearch Center, Dongnam Institute of Radiological and Medical Science, Busan, Republic of Korea. Electronic address: tgson@dirams.re.kr.
Young Seok JuGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Genome Insight, Inc., San Diego, CA 92121, USA. Electronic address: ysju@kaist.ac.kr.
Korea Advanced Institute of Science and Technology · KRDongnam Institute of Radiological & Medical Sciences · KRSeoul National University of Science and Technology · KRSeoul National University · KRInstitute of Molecular Biotechnology · ATWellcome/MRC Cambridge Stem Cell Institute · GBSeoul National University Hospital · KR
Funding
No grant is acknowledged in the PubMed record.
Abstract
The comprehensive genomic impact of ionizing radiation (IR), a carcinogen, on healthy somatic cells remains unclear. Using large-scale whole-genome sequencing (WGS) of clones expanded from irradiated murine and human single cells, we revealed that IR induces a characteristic spectrum of short insertions or deletions (indels) and structural variations (SVs), including balanced inversions, translocations, composite SVs (deletion-insertion, deletion-inversion, and deletion-translocation composites), and complex genomic rearrangements (CGRs), including chromoplexy, chromothripsis, and SV by breakage-fusion-bridge cycles. Our findings suggest that 1 Gy IR exposure causes an average of 2.33 mutational events per Gb genome, comprising 2.15 indels, 0.17 SVs, and 0.01 CGRs, despite a high level of inter-cellular stochasticity. The mutational burden was dependent on total irradiation dose, regardless of dose rate or cell type. The findings were further validated in IR-induced secondary cancers and single cells without clonalization. Overall, our study highlights a comprehensive and clear picture of IR effects on normal mammalian genomes.
Indexed as
Gene RearrangementTranslocation, GeneticAnimalsChromosome InversionGenomicsHumansMammalsMiceMutationcarcinogenclonalizationcomplex genomic rearrangementionizing radiationirradiation dosemutational signaturenormal cellsingle-base substitutionsingle-genome sequencingstructural variation
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