Evidence map›Paper›PMID 38359290›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Mutations of the circadian clock genes

Yanyan Yang, Gang Wu, Aziz Sancar, John B Hogenesch

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yanyan Yang *Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0001-9943-4279
Gang Wu *Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Aziz SancarDepartment of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0001-6469-4900
John B HogeneschDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0002-9138-8973
Cincinnati Children's Hospital Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Molecular Mechanism of Mammalian DNA Excision Repair, DNA Damage Checkpoints and the Circadian ClockR35GM118102 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AZIZ SANCAR · 2016 to 2026
$10.6M
Molecular, Cellular and Physiological Mechanisms of the Mammalian Circadian ClockR01NS054794 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HOGENESCH, JOHN B, LIU, ANDREW C. · 2007 to 2022
$8.1M
Integrated Informatic and Experimental Evaluations of Cancer ChronotherapyR01CA227485 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ANAFI, RON C., HOGENESCH, JOHN B · 2019 to 2023
$3.0M
DNA Adduct Detection and Repair in Mammalian CellsR01ES033414 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANCAR, AZIZ · 2021 to 2025
$2.8M
Circadian Rhythms and Internal DesynchronizationR01HL138551 · NHLBI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI BITTMAN, ERIC L, HOGENESCH, JOHN B · 2018 to 2021
$2.4M
NCI NIH HHS R01 CA227485NHLBI NIH HHS R01 HL138551NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES033414NIGMS NIH HHS R35 GM118102NINDS NIH HHS R01 NS054794
6 · The paper itself

Abstract

One important goal of circadian medicine is to apply time-of-day dosing to improve the efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates DNA repair presents a challenge to mechanism-based clinical application. We studied time-series genome-wide nucleotide excision repair in liver and kidney of wild type and three different clock mutant genotypes (

Indexed as

Circadian ClocksAnimalsARNTL Transcription FactorsCircadian RhythmCLOCK ProteinsCryptochromesMammalsMiceMutationNucleotidesARNTL Transcription FactorsCLOCK ProteinsCryptochromesNucleotidescircadian clockcisplatinDNA repair

Identifiers

PMID38359290
PMCPMC10895256
OpenAlexW4391838863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.