Evidence map›Paper›PMID 38359277›Full record

ArticleACS chemical neuroscience2024

Molecular Pharmacology of Selective Na

Samuel J Goodchild, Noah Gregory Shuart, Aaron D Williams, Wenlei Ye, R Ryley Parrish, Maegan Soriano, Samrat Thouta, Janette Mezeyova, Matthew Waldbrook, Richard Dean and 7 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Ligand-based pharmacophore modeling for the discovery of NaJournal of computer-aided molecular design · 2026
    Article
  3. Voltage-Gated Sodium Channel NaBiochemical genetics · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Small-molecule natural product sophoricoside reduces peripheral neuropathic pain via directly blocking of NaV1.6 in dorsal root ganglion nociceptive neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  13. Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Samuel J GoodchildDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.ORCID 0000-0001-9805-1743
Noah Gregory ShuartDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Aaron D WilliamsDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Wenlei YeNeurocrine Biosciences, San Diego, California 92130, United States.
R Ryley ParrishDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Maegan SorianoDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Samrat ThoutaDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Janette MezeyovaDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Matthew WaldbrookDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Richard DeanDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
Thilo FockenDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.ORCID 0000-0003-1993-2476
Mohammad-Reza GhovanlooDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.ORCID 0000-0002-2171-0744
Peter C RubenDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Fiona ScottNeurocrine Biosciences, San Diego, California 92130, United States.
Charles J CohenDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
James EmpfieldDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.
J P JohnsonDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Voltage-gated sodium channel (Na

Indexed as

EpilepsyVoltage-Gated Sodium ChannelsAction PotentialsBrainHumansNeuronsSeizuresVoltage-Gated Sodium Channelsantiseizure medicationbiophysicsepilepsypharmacologyprecision medicinesodium channel

Identifiers

PMID38359277
PMCPMC10958515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.