Evidence map›Paper›PMID 38359060›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection.

Tianyou Wang, Linghong Guo, Shuwei Wu, Yuanyuan Xu, Junmei Song, Yi Yang, Hengjie Zhang, Dongcui Li, Yiwen Li, Xian Jiang and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianyou WangCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Linghong GuoDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shuwei WuDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yuanyuan XuDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Junmei SongCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Yi YangDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Hengjie ZhangCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Dongcui LiHua An Tang Biotech Group Co., Ltd., Guangzhou, 511434, China.
Yiwen LiCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Xian JiangDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhipeng GuCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.ORCID 0000-0003-4533-6539

Funding

Cadre Research Health Project of Sichuan Province 2022-116Clinical Research Incubation Project of West China Hospital 22HXFH020Fundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of China 52173132National Natural Science Foundation of China 82073473Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine and Sichuan Province 2023MS099Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine and Sichuan Province 2023NSFSC1546Shanghai Ruizhi Pharmaceutical Technology Co., Ltd. Broda Research Fund 2022-04
6 · The paper itself

Abstract

Natural evolution has nurtured a series of active molecules that play vital roles in physiological systems, but their further applications have been severely limited by rapid deactivation, short cycle time, and potential toxicity after isolation. For instance, the instability of structures and properties has greatly descended when sanshool is derived from Zanthoxylum xanthoxylum. Herein, natural polyphenols are employed to boost the key properties of sanshool by fabricating a series of nanoparticles (NPs). The intracellular evaluation and in vivo animal model are conducted to demonstrate the decreased photodamage score and skin-fold thickness of prepared NPs, which can be attributed to the better biocompatibility, improved free radical scavenging, down-regulated apoptosis ratios, and reduced DNA double-strand breaks compared to naked sanshool. This work proposes a novel strategy to boost the key properties of naturally occurring active molecules with the assistance of natural polyphenol-based platforms.

Indexed as

PolyphenolsSkinAnimalsApoptosisDisease Models, AnimalHumansMiceNanoparticlesPlant ExtractsZanthoxylumPlant ExtractsPolyphenolsfree radical scavengingnatural polyphenolsphotodamagesanshoolself‐assembly

Identifiers

PMID38359060
PMCPMC11040382

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.