Evidence map›Paper›PMID 38358918›Full record

ArticleeLife2024

Mapping the architecture of the initiating phosphoglycosyl transferase from

Greg J Dodge, Alyssa J Anderson, Yi He, Weijing Liu, Rosa Viner, Barbara Imperiali

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Proteome-wide bioinformatic annotation and functional validation of the monotopic phosphoglycosyl transferase superfamily.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Greg J DodgeDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.ORCID https://orcid.org/0000-0002-6555-8350
Alyssa J AndersonDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.
Yi HeThermo Fisher Scientific, San Jose, United States.
Weijing LiuThermo Fisher Scientific, San Jose, United States.
Rosa VinerThermo Fisher Scientific, San Jose, United States.
Barbara ImperialiDepartment of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.ORCID https://orcid.org/0000-0002-5749-7869
University of Alberta · CA

Funding

SPECIFICITY IN CO- AND POST-TRANSLATIONAL MODIFICATIONR01GM039334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N., IMPERIALI, BARBARA · 1993 to 2025
$8.0M
Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugatesR01GM131627 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALLEN, KAREN N. · 2019 to 2025
$3.1M
Structural and functional characterization of phosphoglycosyl transferases from human pathogensF32GM134576 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DODGE, GREGORY J · 2019 to 2021
$161k
SPECIFICITY IN CO POST TRANSLATION MODIFICATIONR29GM039334 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI IMPERIALI, BARBARA · 1988 to 1992
–
NIGMS NIH HHS F32 GM134576NIGMS NIH HHS R01 GM039334NIGMS NIH HHS R01 GM131627NIH HHS GM-039334NIH HHS GM-131627NIH HHS GM-134576
6 · The paper itself

Abstract

Bacterial cell surface glycoconjugates are critical for cell survival and for interactions between bacteria and their hosts. Consequently, the pathways responsible for their biosynthesis have untapped potential as therapeutic targets. The localization of many glycoconjugate biosynthesis enzymes to the membrane represents a significant challenge for expressing, purifying, and characterizing these enzymes. Here, we leverage cutting-edge detergent-free methods to stabilize, purify, and structurally characterize WbaP, a phosphoglycosyl transferase (PGT) from the

Indexed as

Salmonella entericaTransferasesCarbohydrate MetabolismCell MembraneO AntigensO AntigensTransferasesbiochemistrychemical biologyE. colielectron microscopyglycoconjugate biosynthesislipopolysaccharidemass spectrometrymembrane proteinmolecular biophysicsS. enterica serovar typhistructural biologystyrene maleic acid copolymer

Identifiers

PMID38358918
PMCPMC10942596
OpenAlexW4388971678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.