ArticleAngewandte Chemie (International ed. in English)2024
Total Synthesis of Dragocins A-C through Electrochemical Cyclization.
Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Electric-Field Catalysis of Diels-Alder Reactions.ACS central science · 2026Article
- Electrochemistry for Sustainable and Low-Carbon Technologies: Energy Conversion, Carbon Neutrality, and Green Chemical Manufacturing.Chemistry, an Asian journal · 2026Review
- Marine natural products.Natural product reports · 2026Review
- Asymmetric C-H Functionalization ofJournal of the American Chemical Society · 2025Article
- Electric-Field Catalysis on Carbon Nanotubes in Electromicrofluidic Reactors: Monoterpene Cyclizations.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The first total synthesis of dragocins A-C, remarkable natural products containing an unusual C4' oxidized ribose architecture bridged by a polyhydroxylated pyrrolidine, is presented through a route featuring a number of uncommon maneuvers. Several generations towards the target molecules are presented, including the spectacular failure of a key C-H oxidation on a late-stage intermediate. The final route features rapid, stereocontrolled access to a densely functionalized pyrrolidine and an unprecedented diastereoselective oxidative electrochemical cyclization to forge the hallmark 9-membered ring. Preliminary studies suggest this electrochemical oxidation protocol is generally useful.
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