Evidence map›Paper›PMID 38358511›Full record

ArticleNeuroradiology2024

Analysis of the initial orbital MRI in aquaporin-4 antibody-positive optic neuritis (AQP4-ON): lesion location and lesion length can be predictive of visual prognosis.

Hanyu Shaw, Chaoyi Feng, Meng Qi, Yalan Deng, Wei Chen, Yiyin Zhang, Luxi Wang, Naier Lin, Guohong Tian, Yan Sha

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Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors at 1 institution in 2 countries.

Hanyu ShawShanghai Institution of Medical Imaging, Shanghai, 200032, China.ORCID http://orcid.org/0009-0005-1092-0278
Chaoyi FengDepartment of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Meng QiDepartment of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Yalan DengDepartment of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Wei ChenShanghai Institution of Medical Imaging, Shanghai, 200032, China.
Yiyin ZhangDepartment of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Luxi WangShanghai Institution of Medical Imaging, Shanghai, 200032, China.
Naier LinDepartment of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Guohong TianDepartment of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. valentian99@hotmail.com.ORCID http://orcid.org/0000-0003-4277-1762
Yan ShaDepartment of Radiology, Eye Ear Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China. cjr.shayan@vip.163.com.ORCID http://orcid.org/0000-0002-4596-8432
Fudan University · CN

Funding

Youth Fund of Shanghai Health Commission 20224Y0318
6 · The paper itself

Abstract

purposeDespite mounting evidence indicating that aquaporin-4 antibody-positive optic neuritis (AQP4-ON) presents a less favorable prognosis than other types of optic neuritis, there exists substantial heterogeneity in the prognostic outcomes within the AQP4-ON cohort. Considering the persistent debate over the role of MRI in assessing the prognosis of optic neuritis, we aim to investigate the correlation between the MRI appearance and long-term visual prognosis in AQP4-ON patients.

methodsWe retrospectively reviewed the ophthalmological and imaging data of AQP4-ON patients admitted to our Neuro-ophthalmology Department from January 2015 to March 2018, with consecutive follow-up visits for a minimum of 3 years.

resultsA total of 51 AQP4-ON patients (59 eyes) meeting the criteria were enrolled in this research. After assessing the initial orbital MR images of each patient at the first onset, we observed the involvement of the canalicular segment (p < 0.001), intracranial segment (p = 0.004), optic chiasm (p = 0.009), and the presence of LEON (p = 0.002) were significantly different between recovery group and impairment group. For quantitative measurement, the length of the lesions is significantly higher in the impairment group (20.1 ± 9.3 mm) than in the recovery group (12.5 ± 5.3 mm) (p = 0.001).

conclusionAQP4-ON patients with involvement of canalicular, intracranial segment and optic chiasm of the optic nerve, and the longer range of lesions threaten worse vision prognoses. Timely MR examination during the initial acute phase can not only exclude the intracranial or orbital mass lesions but also indicate visual prognosis in the long term.

Indexed as

Aquaporin 4Magnetic Resonance ImagingOptic NeuritisAdolescentAdultAgedAutoantibodiesFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesVisual AcuityAquaporin 4AutoantibodiesAquaporin-4 antibodyOptic neuritisOrbital magnetic resonance imageVisual prognosis

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PMID38358511
OpenAlexW4391842676

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