Evidence map›Paper›PMID 38358246›Full record

ArticlemBio2024

The identification of small molecule inhibitors with anthelmintic activities that target conserved proteins among ruminant gastrointestinal nematodes.

Hyeim Jung, Dante Zarlenga, John C Martin, Peter Geldhof, Kymberlie Hallsworth-Pepin, Makedonka Mitreva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Hyeim JungDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-1083-2882
Dante ZarlengaAnimal Parasitic Diseases Laboratory, U.S. Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA.ORCID 0000-0002-8845-1724
John C MartinDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Peter GeldhofLaboratory of Parasitology, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Kymberlie Hallsworth-PepinDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Makedonka MitrevaDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-9572-3436
Washington University in St. Louis · USAgricultural Research Service · USGhent University · BEJames S. McDonnell Foundation · US

Funding

Development of small molecule inhibitors of metabolic enzymes as broad spectrum anthelmintic drugsR01AI159450 · NIAID · WASHINGTON UNIVERSITY · PI JANETKA, JAMES W, MITREVA, MAKEDONKA · 2021 to 2025
$3.9M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI59450NIAID NIH HHS R01 AI159450U.S. Department of Agriculture (USDA) 8042-32000-116-000-D
6 · The paper itself

Abstract

Gastrointestinal nematode (GIN) infections are a major concern for the ruminant industry worldwide and result in significant production losses. Naturally occurring polyparasitism and increasing drug resistance that potentiate disease outcomes are observed among the most prevalent GINs of veterinary importance. Within the five major taxonomic clades, clade Va represents a group of GINs that predominantly affect the abomasum or small intestine of ruminants. However, the development of effective broad-spectrum anthelmintics against ruminant clade Va GINs has been challenged by a lack of comprehensive druggable genome resources. Here, we first assembled draft genomes for three clade Va species (

Indexed as

AnthelminticsCattle DiseasesGastrointestinal DiseasesNematodaNematode InfectionsAnimalsCattleGoatsPhylogenyRuminantsSheepAnthelminticsbroad-spectrum drugsCooperia oncophoradrug targetsgenomesOstertagia ostertagiruminantsTrichostrongylus colubriformis

Identifiers

PMID38358246
PMCPMC10936192
OpenAlexW4391840247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.