Evidence map›Paper›PMID 38357954›Full record

ArticleAnti-inflammatory & anti-allergy agents in medicinal chemistry2024

Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of

Syed A Abbas, Abdullah Khan, Mehraj Fatima, Anandarajagopal Kalusalingam, Mahibub M Kanakal, Shiva K Inamdar, Vijay Kotra, Long C Ming, Ashok K M Dastapur, Tazneem Bachi

Abstract read
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Article in Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Syed A AbbasFaculty of Pharmacy, Quest International University, 30250, Ipoh, Perak, Malaysia.ORCID 0009-0009-2494-3605
Abdullah KhanFaculty of Pharmacy, Quest International University, 30250, Ipoh, Perak, Malaysia.ORCID 0000-0002-3437-8189
Mehraj FatimaDepartment of Pharmacy, HKES's Matoshree Tradevi Ram-pure, Institute of Pharmaceutical Sciences, Kalaburgi, 585105, Karnataka, India.
Anandarajagopal KalusalingamSchool of Pharmacy, KPJ University College, Nilai, Malaysia.ORCID 0000-0002-6422-8798
Mahibub M KanakalFaculty of Pharmacy, Quest International University, 30250, Ipoh, Perak, Malaysia.ORCID 0000-0001-8785-8752
Shiva K InamdarDepartment of Pharmacy, HKES's Matoshree Tradevi Ram-pure, Institute of Pharmaceutical Sciences, Kalaburgi, 585105, Karnataka, India.ORCID 0000-0002-4172-4633
Vijay KotraFaculty of Pharmacy, Quest International University, 30250, Ipoh, Perak, Malaysia.ORCID 0000-0002-2043-4928
Long C MingSchool of Medicine and Life Sciences, Department of Medicine, Sunway University, Kaula Lumpur, Malaysia.ORCID 0000-0002-6971-1383
Ashok K M DastapurDepartment of Pharmacy, HKES's Matoshree Tradevi Ram-pure, Institute of Pharmaceutical Sciences, Kalaburgi, 585105, Karnataka, India.
Tazneem BachiDepartment of Pharmacy, Deccan School of Pharmacy, Darussalam, 500001, Hyderabad, India.ORCID 0000-0003-3220-2988
Quest International University Perak · MYDeccan School of Hospital Management · INNilai University · MYSunway University · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeeds of plant

objectivesThe primary objective of the study was to assess the anti-hemorrhoidal potential of the ethanolic seed extract of

methodsAfter the soxhlet extraction method, the seed extract from

resultsESA demonstrated the presence of flavonoids, saponins, phytosterols, phenols, and tannins. GCMS analysis elucidated the presence of hexadecanoic acid 2 hydroxy -1,3 propane diyl ester,9 Octadecanoic acid ethyl ester, Cyclohexane 1,4 di methyl cis, Farnesol isomer,1, E-11, Z-13 octa decatriene, Stigmasterol, N-(5 ethyl -1,3,4-thiadiazol-yl) benzamide, N, N Dinitro 1,3,5,7 tetraza bicyclo 93,3,1) as major phytoconstituents. The results depicted more potent anti-hemorrhoidal activity of ESA at 1000 mg/kg, p.o., which was evident through a decrease in RAC. A significant decline in the levels of IL-1β, IL-6, and TNF-α expression was observed, along with the restoration of altered antioxidants and enzymes. Histopathological analysis confirmed the tissue recovery as it revealed minimal inflammation and decreased dilated blood vessels in treated animals.

conclusionBased on the results it can be concluded that seeds of

Indexed as

Gas Chromatography-Mass SpectrometryHemorrhoidsPlant ExtractsSeedsAnimalsAnti-Inflammatory AgentsCytokinesMaleRatsRats, WistarAnti-Inflammatory AgentsCytokinesPlant Extractsanti-inflammatoryanti-oxidantGCMShistopathology.PilesScaphium affine

Identifiers

PMID38357954
OpenAlexW4391843678

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.