Evidence map›Paper›PMID 38357791›Full record

ArticleCirculation2024

Clonal Hematopoiesis of Indeterminate Potential With Loss of

Amy Erica Lin, Aneesh C Bapat, Ling Xiao, Abhishek Niroula, Jiangchuan Ye, Waihay J Wong, Mridul Agrawal, Christopher J Farady, Andreas Boettcher, Christopher B Hergott and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
27.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
  2. Understanding the Diseased Atria.Physiology (Bethesda, Md.) · 2026
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  13. Chronic ischemic heart disease: A nonuniform syndrome.American heart journal plus : cardiology research and practice · 2026
    Review
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  16. Gut microbiota dysbiosis promotes chronic kidney disease-associated atrial fibrillation through activation of the NLRP3 inflammasome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 5 countries.

Amy Erica Lin *Division of Cardiovascular Medicine, Department of Medicine (A.E.L., P.L.), Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-0554-2832
Aneesh C Bapat *Cardiovascular Research Center (A.C.B., L.X., J.Y., D.M., P.N., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-1996-522X
Ling XiaoCardiovascular Research Center (A.C.B., L.X., J.Y., D.M., P.N., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-5463-5576
Abhishek NiroulaDepartment of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (A.E.L., A.N., M.A., C.B.H., M.M.C., V.S., B.L.E.).ORCID 0000-0002-5904-0635
Jiangchuan YeCardiovascular Research Center (A.C.B., L.X., J.Y., D.M., P.N., P.T.E.), Massachusetts General Hospital, Boston.
Waihay J WongDepartment of Pathology (W.J.W., C.B.H.), Brigham and Women's Hospital, Boston, MA.ORCID 0000-0003-2023-6590
Mridul AgrawalDepartment of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (A.E.L., A.N., M.A., C.B.H., M.M.C., V.S., B.L.E.).
Christopher J FaradyNovartis Institutes for BioMedical Research Forum 1, Basel, Switzerland (C.J.F., A.B.).ORCID 0000-0002-3607-9721
Andreas BoettcherNovartis Institutes for BioMedical Research Forum 1, Basel, Switzerland (C.J.F., A.B.).ORCID 0000-0002-6548-1015
Christopher B HergottDepartment of Pathology (W.J.W., C.B.H.), Brigham and Women's Hospital, Boston, MA.
Marie McConkeyDepartment of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (A.E.L., A.N., M.A., C.B.H., M.M.C., V.S., B.L.E.).ORCID 0000-0002-9500-018X
Patricio Flores-BringasBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (L.X., A.N., J.Y., P.F.-B., P.N., P.T.E., B.L.E.).
Veronica ShkolnikDepartment of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (A.E.L., A.N., M.A., C.B.H., M.M.C., V.S., B.L.E.).ORCID 0000-0002-9043-1503
Alexander G BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (A.G.B.).ORCID 0000-0001-5824-9595
David MilanCardiovascular Research Center (A.C.B., L.X., J.Y., D.M., P.N., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0003-0149-3110
Pradeep NatarajanCardiovascular Research Center (A.C.B., L.X., J.Y., D.M., P.N., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0001-8402-7435
Peter LibbyDivision of Cardiovascular Medicine, Department of Medicine (A.E.L., P.L.), Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-1502-502X
Patrick T EllinorCardiovascular Research Center (A.C.B., L.X., J.Y., D.M., P.N., P.T.E.), Massachusetts General Hospital, Boston.ORCID 0000-0002-2067-0533
Benjamin L EbertDepartment of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (A.E.L., A.N., M.A., C.B.H., M.M.C., V.S., B.L.E.).ORCID 0000-0003-0197-5451
Broad Institute · USBrigham and Women's Hospital · USDana-Farber Cancer Institute · USNovartis (Switzerland) · CHFondation Leducq · FRMassachusetts General Hospital · USVanderbilt University · US

Funding

TYROSINE KINASE ONCOGENESIS IN MYELOID LEUKEMIAP01CA066996 · NCI · DANA-FARBER CANCER INSTITUTE · PI SCOTT A ARMSTRONG · 1996 to 2026
$52.5M
Targeting SYK Kinase in AMLP50CA206963 · NCI · DANA-FARBER CANCER INST · PI GRAUBERT, TIMOTHY A · 2017 to 2021
$10.6M
Functional Genomic Dissection of Refractory AnemiaR01HL082945 · NHLBI · DANA-FARBER CANCER INSTITUTE · PI EBERT, BENJAMIN LEVINE · 2005 to 2022
$6.8M
The role of clonal hematopoiesis in the development and therapy of myeloid malignanciesR35CA253125 · NCI · DANA-FARBER CANCER INST · PI EBERT, BENJAMIN LEVINE · 2020 to 2024
$4.9M
Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal HematopoiesisR01HL163099 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2022 to 2025
$2.6M
Role of CLCA1 as a MIF decoy inhibitor in abdominal aortic aneurysmsR01HL170000 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter Libby · 2024 to 2026
$2.1M
NCI NIH HHS P01 CA066996NCI NIH HHS P50 CA206963NCI NIH HHS R35 CA253125NHLBI NIH HHS R01 HL082945NHLBI NIH HHS R01 HL163099NHLBI NIH HHS R01 HL170000
6 · The paper itself

Abstract

backgroundClonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk of myocardial infarction and heart failure, the influence of CHIP in cardiac arrhythmias, such as atrial fibrillation (AF), is less explored.

methodsCHIP prevalence was determined in the UK Biobank, and incident AF analysis was stratified by CHIP status and clone size using Cox proportional hazard models. Lethally irradiated mice were transplanted with hematopoietic-specific loss of

resultsAnalysis of the UK Biobank showed individuals with CHIP, in particular

conclusionsWe identified a modest association between CHIP, particularly

Indexed as

Atrial FibrillationClonal HematopoiesisDioxygenasesDNA-Binding ProteinsInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinProto-Oncogene ProteinsAgedAnimalsFemaleHumansMaleMiceMice, KnockoutMiddle AgedMyocytes, CardiacDioxygenasesDNA-Binding ProteinsInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseProto-Oncogene ProteinsTET2 protein, humanTet2 protein, mouseatrial fibrillationclonal hematopoiesisinflammasome

Identifiers

PMID38357791
PMCPMC11058018
OpenAlexW4391840674

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.