ArticleVeterinary medicine and science2024
Metagenomic analysis unravels novel taxonomic differences in the uterine microbiome between healthy mares and mares with endometritis.
Article in Veterinary medicine and science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Detection of papillomavirus DNA in uterine flushing samples from healthy mares reveals diverse genotypes with differing host ranges.Scientific reports · 2026Article
- Characterization of the Endometrial Microbiota of Healthy Mares Across the Estrous Cycle.Animals : an open access journal from MDPI · 2026Article
- The Uterine Microbiota in Mares With Endometritis: Impacts of Antibiotic Treatment.Veterinary medicine international · 2026Article
- Evidence-based interpretation of uterine cultures in mares: Linking bacterial growth patterns to endometrial inflammation.PloS one · 2026Article
- Effects of Intra-uterine Ceftiofur on the Equine Uterine Microbiome.Veterinary sciences · 2025Article
- Comparison of RNA- and DNA-based 16S amplicon sequencing to find the optimal approach for the analysis of the uterine microbiome.Scientific reports · 2025Article
- Lactobacillus Genus Complex Probiotic-Induced Changes on the Equine Clitoral Microbiome.Veterinary sciences · 2025Article
- Article
- Fundamentals of microbiome-based therapies for reproductive tract inflammatory diseases in domestic animals.Animal reproduction · 2025Review
- Reproductive Tract Microbiota of Mares.Veterinary sciences · 2024Review
- Vaginal and Uterine Microbiota of Healthy Maiden Mares during Estrus.Veterinary sciences · 2024Article
- Metagenomic analysis unravels novel taxonomic differences in the uterine microbiome between healthy mares and mares with endometritis.Veterinary medicine and science · 2024Article
- Correlation between microbial characteristics and reproductive status of the yak uterus based on macrogenomic analysis.BMC veterinary research · 2024Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe application of high throughput technologies has enabled unravelling of unique differences between healthy mares and mares with endometritis at transcriptomic and proteomic levels. However, differences in the uterine microbiome are yet to be investigated.
objectivesThe present study was aimed at evaluating the differences in uterine microbiome between healthy mares and mares with endometritis.
methodsLow-volume lavage (LVL) samples were collected from the uterus of 30 mares classified into healthy (n = 15) and endometritis (n = 15) based on their reproductive history, intrauterine fluid accumulation, gross appearance of LVL samples, endometrial cytology and bacterial culture. The samples were subjected to 16S rRNA sequencing.
resultsNotable differences in the uterine microbiome were observed between healthy mares and mares with endometritis at various taxonomic levels. In healthy mares, the most abundant phylum, class, order and family were Firmicutes, Bacilli, Bacillales and Paenibacillaceae, respectively. In contrast, the most abundant corresponding taxonomic levels in mares with endometritis were Proteobacteria, Gammaproteobacteria, Enterobacterales and Enterobacteriaceae, respectively. At the genus level, Brevibacillus and Paenibacillus were more abundant in healthy mares, whereas Escherichia, Salmonella and Klebsiella were more abundant in mares with endometritis. In healthy mares, Brevibacillus brevis was the most abundant species, followed by Brevibacillus choshinensis and Paenibacillus sp JDR-2. However, in mares with endometritis, Escherichia coli was the most abundant species, followed by Salmonella enterica and Klebsiella pneumoniae.
conclusionsThese results confirmed the previously reported presence of a uterine microbiome in healthy mares and helped unravel some alterations that occur in mares with endometritis. The findings can potentially help formulate new approaches to prevent or treat equine endometritis.
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