ArticleMedical hypothesis, discovery & innovation ophthalmology journal2023
Outcomes of the Q value-based nomogram in managing pediatric versus adult keratoconus: a prospective interventional study.
Article in Medical hypothesis, discovery & innovation ophthalmology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Advances in Intracorneal Ring Segment (ICRS) Implantation for Keratoconus: A Comprehensive Literature Review, Clinical Insights, and Future Prospects.Journal of clinical medicine · 2025Review
- Intracorneal ring segment implantation for eyes with keratoconus and corneas thinner than 400 microns.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Article
- Corneal densitometry changes after femtosecond laser-assisted intracorneal ring segments implantation in keratoconus.Medical hypothesis, discovery & innovation ophthalmology journal · 2024Article
- Keratoconus: imaging modalities and management.Medical hypothesis, discovery & innovation ophthalmology journal · 2024Review
- Thyroid gland dysfunction and keratoconus.Medical hypothesis, discovery & innovation ophthalmology journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Keratoconus (KCN) is an ectatic disorder of the cornea characterized by stromal weakness and apical protrusion of the cornea, and is associated with a gradual and painless reduction in visual acuity. KCN in pediatric patients has certain important characteristics, such as a progressive and aggressive nature. We aimed to analyze the visual, refractive, and topographic outcomes of implanting a single 210° arc-length Keraring segment according to a novel, objective, Q value-based nomogram (Q-N) for the treatment of pediatric versus adult KCN. Methods: This prospective, multicenter, non-randomized, open-label trial included 47 eyes of 47 patients who were allocated to one of two groups. The Results: The study groups were comparable in terms of sex proportions and KCN grades (both Conclusions: Use of the objective Q-N was efficient in the treatment of pediatric KCN, with postoperative improvements in the mean visual, refractive, and topographic parameters, comparable to outcomes in adult keratoconus. Q-N achieved good corneal remodeling with subsequent improvements in visual, refractive, and topographic outcomes in both adult and pediatric patients with keratoconus. To verify our preliminary findings, we recommend further multicenter randomized clinical trials using the Q-N nomogram in a larger sample of pediatric patients with KCN as an adjunct treatment before or after CXL.
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Registered trials
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