Evidence map›Paper›PMID 38357545›Full record

ArticleFrontiers in immunology2024

Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus.

Kerry Newbrook, Nakibul Khan, Aimee Fisher, Karen Chong, Simon Gubbins, William C Davies, Christopher Sanders, Marc Guimerà Busquets, Lyndsay Cooke, Amanda Corla and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
8.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Kerry NewbrookOrbivirus Research, The Pirbright Institute, Woking, United Kingdom.
Nakibul KhanOrbivirus Research, The Pirbright Institute, Woking, United Kingdom.
Aimee FisherOrbivirus Research, The Pirbright Institute, Woking, United Kingdom.
Karen ChongOrbivirus Research, The Pirbright Institute, Woking, United Kingdom.
Simon GubbinsTransmission Biology, The Pirbright Institute, Woking, United Kingdom.
William C DaviesDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, United States.
Christopher SandersEntomology, The Pirbright Institute, Woking, United Kingdom.
Marc Guimerà BusquetsOrbivirus Research, The Pirbright Institute, Woking, United Kingdom.
Lyndsay CookeOrbivirus Research, The Pirbright Institute, Woking, United Kingdom.
Amanda CorlaNon Vesicular Reference Laboratory, The Pirbright Institute, Woking, United Kingdom.
Martin AshbyNon Vesicular Reference Laboratory, The Pirbright Institute, Woking, United Kingdom.
John FlanneryNon Vesicular Reference Laboratory, The Pirbright Institute, Woking, United Kingdom.
Carrie BattenNon Vesicular Reference Laboratory, The Pirbright Institute, Woking, United Kingdom.
Jessica E StokesEntomology, The Pirbright Institute, Woking, United Kingdom.
Beatriz Sanz-BernardoLarge Deoxyribonucleic Acid (DNA), Viruses, The Pirbright Institute, Woking, United Kingdom.
Simon CarpenterEntomology, The Pirbright Institute, Woking, United Kingdom.
Katy MoffatFlow Cytometry, The Pirbright Institute, Woking, United Kingdom.
Karin E DarpelOrbivirus Research, The Pirbright Institute, Woking, United Kingdom.
The Pirbright Institute · GBUniversity of Bern · CHUniversity of Surrey · GBUniversity of York · GBWashington State University · US

Funding

Biotechnology and Biological Sciences Research Council BBS/E/I/00007033
6 · The paper itself

Abstract

Introduction: Bluetongue virus (BTV) is an arthropod-borne Methods: In this study, the role of cell-mediated immunity and specific T-cell subsets in BTV pathogenesis, clinical outcome, viral dynamics, immune protection, and onwards transmission to a susceptible Results: The absence of cytotoxic CD8 Discussion: This study identifies a diverse repertoire of T-cell functions during BTV infection in sheep, particularly in inducing specific anti-viral immune responses and disease manifestation, and will support more effective vaccination strategies.

Indexed as

ArbovirusesBluetongueBluetongue virusCeratopogonidaeAnimalsCD8-Positive T-LymphocytesLivestockRuminantsSheepT-Lymphocyte SubsetsViremiaBluetongue virusCulicoidesimmunityOrbiviruspathogenesisT cell

Identifiers

PMID38357545
PMCPMC10864546
OpenAlexW4391398235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.