ReviewFrontiers in behavioral neuroscience2024
Postoperative cognitive dysfunction-current research progress.
Review in Frontiers in behavioral neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 8 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Comparative efficacy and safety of multiple acupoint electrical stimulation therapies for postoperative cognitive dysfunction in cancer patients: a network meta-analysis.Systematic reviews · 2026Pooled it
- Comparing sugammadex to neostigmine and their effects on delirium and postoperative cognitive function: A systematic review.Journal of perioperative practice · 2026Pooled it
- Association between BDNF and postoperative cognitive dysfunction across surgical stages: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Remimazolam vs propofol for postoperative delirium in adults undergoing general anesthesia: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- The significance of S100β and neuron-specific enolase (NSE) in postoperative cognitive dysfunction following cardiac surgery: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Preoperative Protein Profiling Among Postoperative Cognitive Dysfunction (POCD) Patients Following Open-Heart Surgery: A Systematic Review and Integrated Bioinformatic Analysis.International journal of molecular sciences · 2024Pooled it
- Prediction models for postoperative cognitive dysfunction in adults: a systematic review of methodological quality and clinical applicability.Frontiers in neurologyPooled it
- Effect of dexmedetomidine on postoperative cognitive function in patients with gastrointestinal cancer: a meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- Effect of pericapsular nerve group block on postoperative cognitive function in older patients undergoing total hip arthroplasty.Die Anaesthesiologie · 2026Trial
- Effects of Esketamine on Postoperative Delirium and Postoperative Cognitive Function in Elderly Gastrointestinal Tumor Patients with Preoperative Anxiety.Drug design, development and therapy · 2025Trial
- Desflurane Increases Hippocampal RAF-MAPK-MSK1 Protein Levels and Reduces CLOCK Expression: Sorafenib Attenuates Cognitive Impairment in Aged Mice.Neurochemical research · 2026Article
- Preventive effect of ulinastatin on postoperative cognitive dysfunction through modulation of the gut microbiome: evidence from short-chain fatty acids.Brain, behavior, & immunity - health · 2026Article
- Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia.Healthcare (Basel, Switzerland) · 2026Review
- From heart to mind: A narrative review of incidence, risk factors, and mechanisms of dementia after cardiac surgery.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Effect of hospitalization on cognitive and physical function in people with HIV.AIDS (London, England) · 2026Article
- FOXM1 downregulation contributes to sevoflurane-induced microglial dysfunction via transcriptional downregulation of RGS10.Experimental brain research · 2026Article
- Deep cerebellar stimulation restores chronic motor deficits and loss of GABAergic neurons following sensorimotor cortex surgical brain injury in female rats.Experimental neurology · 2026Article
- Network pharmacology and experimental verification to explore the therapeutic mechanism of esketamine in postoperative cognitive dysfunction.Molecular and cellular biochemistry · 2026Article
- USF1-mediated transcription of PARP1 contributes to sevoflurane-induced pyroptosis in perioperative neurocognitive disorders.Functional & integrative genomics · 2026Article
- Excitation-inhibition imbalance underlies perioperative neurocognitive disorders: a single-nucleus transcriptomic perspective in mice hippocampus.Molecular psychiatry · 2026Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD can reach 40% within 1 week following cardiovascular surgery and remains as high as 17% 3 months post-surgery. Furthermore, POCD exacerbates the long-term risk of Alzheimer's disease (AD). As a result, numerous studies have been conducted to investigate the molecular mechanisms underlying POCD and potential preventive strategies. This article provides a review of the research progress on POCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.