Evidence map›Paper›PMID 38357291›Full record

ArticleTrauma case reports2024

Off-label: The results of adjunctive bone morphogenetic protein for challenging femur fractures; a review of two cases.

Julia Anne Prodoehl, Yianni Bakaes, Michael Tucker, Frank Voss

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Trauma case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Julia Anne ProdoehlPrisma Health Midlands Department of Orthopaedic Surgery, 2 Medical Park Rd, Columbia, SC 29203, United States of America.
Yianni BakaesUniversity of South Carolina School of Medicine Columbia, 2 Medical Park Rd, Columbia, SC 29203, United States of America.
Michael TuckerPrisma Health Midlands Department of Orthopaedic Surgery, 2 Medical Park Rd, Columbia, SC 29203, United States of America.
Frank VossMedical University of South Carolina Department of Orthopaedic Surgery, 135 Rutledge Ave., Charleston, SC 29425, United States of America.
Prisma Health · USMedical University of South Carolina · USUniversity of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although bone morphogenetic proteins (BMPs) are used as an adjunct to promote healing, they may have unintended effects such as heterotopic ossification (HO). The literature is limited regarding the effect of using off-label BMPs for femur fractures. Case presentation: We report two outcomes after off-label use of BMPs for the treatment of femur fractures and propose a possible explanation for the difference. Conclusions: BMPs are critical osteoinductive factors in injured bone and muscle that facilitate bony healing. However, it may be important to recognize the potentially negative effects of adding BMP to bone graft material in certain cases to stimulate bone repair. We hope this case series helps surgeons consider the risks and benefits of using BMP for femur fractures, and therefore to decide with caution when BMP is indicated.

Indexed as

Bone morphogenetic protein (BMP)Femur fractureHeterotropic ossificationOff-label use

Identifiers

PMID38357291
PMCPMC10863425
OpenAlexW4391672487

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.