Evidence map›Paper›PMID 38356877›Full record

ArticleCanada communicable disease report = Releve des maladies transmissibles au Canada2023

Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada.

Daniel Farrar, Charlotte Moore Hepburn, Olivier Drouin, Tala El Tal, Marie-Paule Morin, Roberta Berard, Melanie King, Melanie Laffin Thibodeau, Krista Baerg, Guillaume Beaudoin-Bussières and 32 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canada communicable disease report = Releve des maladies transmissibles au Canada, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 15 institutions in 3 countries.

Daniel FarrarCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON.
Charlotte Moore HepburnDivision of Paediatric Medicine, The Hospital for Sick Children, Toronto, ON.
Olivier DrouinDivision of General Paediatrics, Department of Paediatrics, CHU Sainte-Justine, Montréal, QC.
Tala El TalDivision of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, ON.
Marie-Paule MorinDivision of Paediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Paediatrics, University of Montreal, Montréal, QC.
Roberta BerardDivision of Rheumatology, Department of Paediatrics, Children's Hospital at London Health Sciences Centre, London, ON.
Melanie KingCanadian Paediatric Surveillance Program, Canadian Paediatric Society, Ottawa, ON.
Melanie Laffin ThibodeauCanadian Paediatric Surveillance Program, Canadian Paediatric Society, Ottawa, ON.
Krista BaergDepartment of Paediatrics, University of Saskatchewan, Saskatoon, SK.
Guillaume Beaudoin-BussièresCentre de Recherche du CHUM et Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC.
Camille BeaufilsDivision of Paediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Paediatrics, University of Montreal, Montréal, QC.
Terri-Lyn BennettPublic Health Agency of Canada, Ottawa, ON.
Susanne BenselerAlberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB.
Kevin ChanDepartment of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON.
Claude CyrService de Soins Intensifs Pédiatriques, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC.
Nagib DahdahDivision of Paediatric Cardiology, CHU Sainte-Justine, Department of Paediatrics, University of Montréal, Montréal, QC.
Elizabeth DonnerDepartment of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON.
Joanne EmbreeDepartment of Paediatrics and Child Health, University of Manitoba, Winnipeg, MB.
Catherine FarrellDivision of Paediatric Intensive Care, Department of Paediatrics, CHU Sainte-Justine, Montréal, QC.
Andrés FinziCentre de Recherche du CHUM et Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC.
Sarah ForgieDivision of Infectious Diseases, Department of Paediatrics, University of Alberta, Edmonton, AB.
Ryan GirouxWomen's and Children's Health Program, St. Michael's Hospital, Unity Health Toronto, Toronto, ON.
Kristopher KangDepartment of Paediatrics, University of British Columbia, Vancouver, BC.
Bianca LangDivision of Rheumatology, Department of Paediatrics, Dalhousie University, Halifax, NS.
Ronald LaxerDivision of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, ON.
Brian McCrindleThe Labatt Family Heart Centre, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON.
Julia OrkinDivision of Paediatric Medicine, The Hospital for Sick Children, Toronto, ON.
Jesse PapenburgDivision of Paediatric Infectious Diseases, Department of Paediatrics, Montreal Children's Hospital, Montréal, QC.
Catherine PoundDivision of Consulting Paediatrics, Department of Paediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON.
Victoria PriceDivision of Paediatric Hematology/Oncology, Department of Paediatrics, Dalhousie University, Halifax, NS.
Jean-Phillippe Proulx-GauthierDivision of Paediatric Rheumatology, Department of Paediatrics, CHU de Québec-Université Laval, Québec City, QC.
Rupeena PurewalDepartment of Paediatrics, University of Saskatchewan, Saskatoon, SK.
Manish SadaranganiDepartment of Paediatrics, University of British Columbia, Vancouver, BC.
Marina SalvadoriPublic Health Agency of Canada, Ottawa, ON.
Roseline ThibeaultDivision of Infectious Diseases, Department of Paediatrics, CHU de Québec-Université Laval, Québec City, QC.
Karina TopDepartment of Paediatrics, Dalhousie University, Halifax, NS.
Isabelle Viel-ThériaultDivision of Infectious Diseases, Department of Paediatrics, CHU de Québec-Université Laval, Québec City, QC.
Elie HaddadDivision of Paediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Paediatrics, University of Montreal, Montréal, QC.
Rosie ScuccimarriDivision of Paediatric Rheumatology, Montreal Children's Hospital and McGill University Health Centre, Montréal, QC.
Rae YeungDivision of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, ON.
Fatima KakkarDivision of Infectious Diseases, CHU Sainte-Justine, Montréal, QC.
Shaun MorrisCentre for Global Child Health, The Hospital for Sick Children, Toronto, ON.
University of Toronto · CADalhousie University · CACentre Hospitalier Universitaire Sainte-Justine · CASaskatchewan Health Authority · CAUniversity of British Columbia · CACanadian Paediatric Society · CAMontreal Children's Hospital · CAPublic Health Agency of Canada · CAUniversity of Alberta · CAUniversity of Calgary · CACentre Hospitalier Universitaire de Sherbrooke · CAChildren's Hospital of Eastern Ontario · CAGreat Ormond Street Hospital · GBHospital for Sick Children · CALondon Health Sciences Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Direct comparisons of paediatric hospitalizations for acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning. We describe the absolute and relative hospital burden of acute paediatric COVID-19 and MIS-C in Canada. Methods: This national prospective study was conducted via the Canadian Paediatric Surveillance Program from March 2020-May 2021. Children younger than 18 years old and hospitalized for acute COVID-19 or MIS-C were included in the analysis. Outcomes included supplemental oxygen (low-flow oxygen or high-flow nasal cannula), ventilation (non-invasive or conventional mechanical), vasopressors, paediatric intensive care unit (PICU) admission, or death. Adjusted risk differences (aRD) and 95% confidence intervals (CI) were calculated to identify factors associated with each diagnosis. Results: Overall, we identified 330 children hospitalized for acute COVID-19 (including five deaths) and 208 hospitalized for MIS-C (including zero deaths); PICU admission was required for 49.5% of MIS-C hospitalizations versus 18.2% of acute COVID-19 hospitalizations (aRD 20.3; 95% CI, 9.9-30.8). Resource use differed by age, with children younger than one year hospitalized more often for acute COVID-19 (aRD 43.4% versus MIS-C; 95% CI, 37.7-49.1) and more children 5-11 years hospitalized for MIS-C (aRD 38.9% vs. acute COVID-19; 95% CI, 31.0-46.9). Conclusion: While there were more hospitalizations and deaths from acute paediatric COVID-19, MIS-C cases were more severe, requiring more intensive care and vasopressor support. Our findings suggest that both acute COVID-19 and MIS-C should be considered when assessing the overall burden of severe acute respiratory syndrome coronavirus 2 in hospitalized children.

Indexed as

COVID-19hospitalizationsintensive careMIS-Cmultisystem inflammatory syndrome in childrenpaediatricsresource useSARS-CoV-2surveillance

Identifiers

PMID38356877
PMCPMC10866613
OpenAlexW4365446828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.