Evidence map›Paper›PMID 38356864›Full record

ArticleCritical care explorations2024

EPidemiology, clinical characteristics and Outcomes of 4546 adult admissions to high-dependency and intensive care units in Kenya (EPOK): a multicentre registry-based observational study.

Carolyne Njoki, Nabukwangwa Simiyu, Ronnie Kaddu, Wambui Mwangi, Demet Sulemanji, Peter Oduor, Dilanthi Gamage Dona, Dorothy Otieno, Teddy Thaddeus Abonyo, Patricia Wangeci and 11 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05456217 (Clinical Characteristics and Outcomes of Patients Admitted to Kenyan Critical Care Units During the COVID-19 Pandemic), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05456217 unknown statusnot on this map

Clinical Characteristics and Outcomes of Patients Admitted to Kenyan Critical Care Units During the COVID-19 Pandemic: a Multicenter Registry-based Observational Study

Typeobservational_patient_registrySponsorNat Intensive Care Surveillance - MORURan2021 to 2022Enrolled4,000ConditionsOutcome Studies, Mechanical Ventilation, KenyaArmsadmission to ICU
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Carolyne NjokiDepartment of Anesthesia, Aga Khan University, Nairobi, Kenya.
Nabukwangwa SimiyuDepartment of Anesthesia and Intensive Care, Kisii Hospital, Kisii, Kenya.
Ronnie KadduIntensive Care Unit, Aga Khan Mombasa Hospital (AKM), Mombasa, Kenya.
Wambui MwangiIntensive Care Unit, Nyeri County Hospital, Nyeri, Kenya.
Demet SulemanjiDepartment of Anesthesia and Intensive Care, MP Shah Hospital, Nairobi, Kenya.
Peter OduorDepartment of Anesthesia and Intensive Care, Nakuru referral Hospital, Nakuru, Kenya.
Dilanthi Gamage DonaNat Intensive Care Surveillance-MORU, Colombo, Sri Lanka.
Dorothy OtienoCritical Care Society of Kenya, Nairobi, Kenya.
Teddy Thaddeus AbonyoDepartment of Anesthesia, Aga Khan University, Nairobi, Kenya.
Patricia WangeciDepartment of Anesthesia and Intensive Care, Nakuru referral Hospital, Nakuru, Kenya.
Thomas KabanyaIntensive Care Unit, Nyeri County Hospital, Nyeri, Kenya.
Selina MutukuIntensive Care Unit, Aga Khan Mombasa Hospital (AKM), Mombasa, Kenya.
Annastacia KiokoDepartment of Anesthesia and Intensive Care, Kisii Hospital, Kisii, Kenya.
Joy MuthoniIntensive Care Unit, Aga Khan Mombasa Hospital (AKM), Mombasa, Kenya.
Peter Mburu KamauDepartment of Anesthesia and Intensive Care, MP Shah Hospital, Nairobi, Kenya.
Abigail BeaneNat Intensive Care Surveillance-MORU, Colombo, Sri Lanka.
Rashan HaniffaNat Intensive Care Surveillance-MORU, Colombo, Sri Lanka.
Arjen DondorpMahidol Oxford Tropical Research Unit, Bangkok, Thailand.
David MisangoDepartment of Anesthesia, Aga Khan University, Nairobi, Kenya.
Luigi PisaniMahidol Oxford Tropical Research Unit, Bangkok, Thailand.
Wangari Waweru-SiikaDepartment of Anesthesia, Aga Khan University, Nairobi, Kenya.
Aga Khan University Nairobi · KEAga Khan Hospital, Mombasa · KEMahidol Oxford Tropical Medicine Research Unit · THChild Welfare Society of Kenya · KENairobi Hospital · KE

Funding

Medical Research Council MR/V030884/1Wellcome Trust
6 · The paper itself

Abstract

Objective: to describe clinical, management and outcome features of critically ill patients admitted to intensive care units (ICUs) and high dependency units (HDUs) in Kenya. Design: prospective registry-based observational study. Setting: three HDUs and eight ICUs in Kenya. Patients: consecutive adult patients admitted between January 2021 and June 2022. Interventions: none. Measurements and main results: data was entered in a cloud based platform using a common data model. Study endpoints included case mix variables, management features and patient centred outcomes. Patients with Coronavirus disease 2019 (COVID-19) were reported separately. Of the 3892/4546 patients without COVID-19, 2445 patients (62.8%) were from HDUs and 1447 (37.2%) from ICUs. Patients had a median age of 53 years (interquartile range [IQR] 38-68), with HDU patients being older but with a lower severity (APACHE II 6 [3-9] in HDUs vs 12 [7-17] in ICUs; p<0.001). One out of four patients were postoperative with 604 (63.4%) receiving emergency surgery. Readmission rate was 4.8%. Hypertension and diabetes were prevalent comorbidities, with a 4.0% HIV/AIDS rate. Invasive mechanical ventilation (IMV) was applied in 3.4% in HDUs vs. 47.6% in ICUs (P<0.001), with a duration of 7 days (IQR 3-21). There was a similar use of renal replacement therapy (4.0% vs. 4.7%; P<0.001). Vasopressor use was infrequent while half of patients received antibiotics. Average length of stay was 2 days (IQR 1-5). Crude HDU mortality rate was 6.5% in HDUs versus 30.5% in the ICUs (P<0.001). Of the 654 COVID-19 admissions, most were admitted in ICUs (72.3%) with a 33.2% mortality. Conclusions: We provide the first multicenter observational cohort study from an African ICU national registry. Distinct management features and outcomes characterise HDU from ICU patients. Study registration: Clinicaltrials.gov (reference number NCT05456217, date of registration 07 Nov 2022).

Indexed as

high dependency unitIntensive care unitKenyaoutcomesregistry

Identifiers

PMID38356864
PMCPMC7615640
OpenAlexW4391542302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.