ArticlePakistan journal of medical sciences
Relationship between baseline mean platelet volume (MPV) and prognosis of patients with acute mild cerebral infarction undergoing intravenous thrombolysis with Alteplase.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Correlation analysis of Serum Hcy, HMGB1, and TLR4 levels and mononuclear macrophage polarisation in acute cerebral infarction.Journal of medical biochemistry · 2026Article
- A predictive model for early neurological deterioration after intravenous thrombolysis in patients with ischemic stroke.Frontiers in neurology · 2025Article
- Prognostic value of mean platelet volume and platelet distribution width for the outcomes of patients with acute ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.American journal of translational research · 2025Article
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4 authors.
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Abstract
Objective: To investigate the relationship between baseline, mean platelet volume (MPV) and prognosis of patients with acute mild cerebral infarction undergoing intravenous thrombolysis with alteplase. Methods: A retrospective analysis was conducted of clinical imaging and laboratory data of patients with acute mild cerebral infarction who received intravenous thrombolytic therapy with alteplase in Baoding No.1 Central Hospital between March 2018 and March 2021. According to mRS scores after three months, a total of 140 patients were divided into the good prognosis group(n=115) (mRS score <two) and the poor prognosis group(n=25) (mRS score ≥two). Logistic regression analysis was employed to investigate MPV and other factors that may affect the prognosis. The ROC curve of subjects was used to predict the prognosis of influencing factors. Possible influencing factors of early neurological deterioration (END) were also analyzed. Results: Logistic regression analysis showed that 24 hour NIHSS score after thrombolysis and baseline MPV were independently correlated with 3-month prognosis. The ROC curve indicated an optimal cutoff value of 9.65 fl for MPV in predicting poor prognosis. The study also found that the increase of baseline MPV had a close bearing on the risk increase of END. Conclusion: Baseline MPV is an independent risk factor for early neurological deterioration and three months poor prognosis in patients with acute mild cerebral infarction undergoing intravenous thrombolysis.
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