Evidence map›Paper›PMID 38356632›Full record

ArticleNanoscale advances2024

Vortex fluidic regulated phospholipid equilibria involving liposomes down to sub-micelle size assemblies.

Nikita Joseph, Marzieh Mirzamani, Tarfah Abudiyah, Ahmed Hussein Mohammed Al-Antaki, Matt Jellicoe, David P Harvey, Emily Crawley, Clarence Chuah, Andrew E Whitten, Elliot Paul Gilbert and 5 more

Abstract read
In one paragraph

Article in Nanoscale advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nikita JosephFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.
Marzieh MirzamaniJames L. Winkle College of Pharmacy, University of Cincinnati Cincinnati OH 45267-0004 USA kumariha@ucmail.uc.edu.
Tarfah AbudiyahFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.
Ahmed Hussein Mohammed Al-AntakiFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.ORCID https://orcid.org/0000-0001-8576-3805
Matt JellicoeFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.
David P HarveyFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.
Emily CrawleyFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.
Clarence ChuahFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.
Andrew E WhittenAustralian Nuclear Science and Technology Organisation (ANSTO) Lucas Heights NSW 2234 Australia.ORCID https://orcid.org/0000-0001-8856-3120
Elliot Paul GilbertAustralian Nuclear Science and Technology Organisation (ANSTO) Lucas Heights NSW 2234 Australia.ORCID https://orcid.org/0000-0001-6413-7813
Shuo QianThe Second Target Station Project of SNS, Oak Ridge National Laboratory Oak Ridge TN 37830 USA.ORCID https://orcid.org/0000-0002-4842-828X
Lilin HeNeutron Scattering Division, Oak Ridge National Laboratory Oak Ridge TN 37830 USA.ORCID https://orcid.org/0000-0002-9560-8101
Michael Z MichaelFlinders Centre for Innovation in Cancer (FCIC), Flinders Medical Centre (FMC) Bedford Park SA 5042 Australia.
Harshita KumariJames L. Winkle College of Pharmacy, University of Cincinnati Cincinnati OH 45267-0004 USA kumariha@ucmail.uc.edu.ORCID https://orcid.org/0000-0002-6861-0281
Colin L RastonFlinders Institute for Nanoscale Science and Technology, College of Science and Engineering, Flinders University Bedford Park SA 5042 Australia colin.raston@flinders.edu.au.ORCID https://orcid.org/0000-0003-4753-0079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional channel-based microfluidic platforms have gained prominence in controlling the bottom-up formation of phospholipid based nanostructures including liposomes. However, there are challenges in the production of liposomes from rapidly scalable processes. These have been overcome using a vortex fluidic device (VFD), which is a thin film microfluidic platform rather than channel-based, affording ∼110 nm diameter liposomes. The high yielding and high throughput continuous flow process has a 45° tilted rapidly rotating glass tube with an inner hydrophobic surface. Processing is also possible in the confined mode of operation which is effective for labelling pre-VFD-prepared liposomes with fluorophore tags for subsequent mechanistic studies on the fate of liposomes under shear stress in the VFD.

Identifiers

PMID38356632
PMCPMC10863723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.