Evidence map›Paper›PMID 38356344›Full record

Trial reportGut and liver2024

Immune-Enhancing Treatment among Acute Necrotizing Pancreatitis Patients with Metabolic Abnormalities: A

Xiaofei Huang, Wenjian Mao, Xingxing Hu, Fengxia Qin, Hui Zhao, Aiping Zhang, Xinyu Wang, Christian Stoppe, Dandan Zhou, Lu Ke and 2 more

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Gut and liver, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02473406 (Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02473406 phase4completednot on this map

Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis

TypeinterventionalSponsorWeiqin LiRan2018 to 2021Enrolled508ConditionsPancreatitis, Acute NecrotizingArmsThymosin Alpha 1, normal saline
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Xiaofei HuangDepartment of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0009-0001-7780-5865
Wenjian MaoDepartment of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.ORCID 0000-0002-0033-8939
Xingxing HuDepartment of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0000-0001-6385-4845
Fengxia QinDepartment of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0009-0000-7256-1884
Hui ZhaoDepartment of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0009-0004-9181-5308
Aiping ZhangDepartment of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0009-0008-5559-2943
Xinyu WangDepartment of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.ORCID 0009-0004-6603-514X
Christian StoppeDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0002-2028-2039
Dandan ZhouDepartment of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0000-0002-4041-5150
Lu KeDepartment of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.ORCID 0000-0001-8093-5073
Haibin NiDepartment of Emergency and Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0000-0003-1726-7943
Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)
Nanjing University of Chinese Medicine · CNNanjing General Hospital of Nanjing Military Command · CNUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Metabolic syndrome is common in patients with acute pancreatitis and its components have been reported to be associated with infectious complications. In this Methods: All data were obtained from the database for a multicenter randomized clinical trial that evaluated the efficacy of Tα1 in ANP patients. Patients who discontinued the Tα1 treatment prematurely were excluded. The primary outcome was 90-day infected pancreatic necrosis (IPN) after randomization. Three Results: Overall, 502 participants were included in this Conclusions: Among ANP patients with hyperglycemia, immune-enhancing Tα1 treatment was associated with a reduced risk of IPN (ClinicalTrials.gov, Registry number: NCT02473406).

Indexed as

HyperglycemiaHypertriglyceridemiaPancreatitis, Acute NecrotizingThymalfasinAdultAgedFemaleHumansMaleMetabolic SyndromeMiddle AgedPropensity ScoreProportional Hazards ModelsThymosinTreatment OutcomeThymalfasinThymosinAcute necrotizing pancreatitisHyperglycemiaInfectionMetabolic syndromeThymosin alpha1

Identifiers

PMID38356344
PMCPMC11391137
OpenAlexW4391841359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.