Evidence map›Paper›PMID 38356025›Full record

ArticlePediatric research2024

The effect of vibrotactile stimulation on hypoxia-induced irregular breathing and apnea in preterm rabbits.

Sophie J E Cramer, Janneke Dekker, Michelle K Croughan, Katie L Lee, Kelly J Crossley, Erin V McGillick, Tessa Martherus, Martha Thio, Megan J Wallace, Marcus J Kitchen and 2 more

Open access · greenAbstract read
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In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sophie J E CramerWillem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands. s.j.e.cramer@lumc.nl.
Janneke DekkerWillem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
Michelle K CroughanSchool of Physics and Astronomy, Monash University, Melbourne, VIC, Australia.
Katie L LeeSchool of Physics and Astronomy, Monash University, Melbourne, VIC, Australia.
Kelly J CrossleyThe Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Erin V McGillickThe Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Tessa MartherusWillem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
Martha ThioWomen's Newborn Research Centre, The Royal Women's Hospital, Melbourne, VIC, Australia.
Megan J WallaceThe Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Marcus J KitchenSchool of Physics and Astronomy, Monash University, Melbourne, VIC, Australia.
Stuart B HooperThe Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Arjan B Te PasWillem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
Hudson Institute of Medical Research · AULeiden University Medical Center · NLMonash University · AUMurdoch Children's Research Institute · AU

Funding

NHMRC
6 · The paper itself

Abstract

backgroundManual tactile stimulation is used to counteract apnea in preterm infants, but it is unknown when this intervention should be applied. We compared an anticipatory to a reactive approach using vibrotactile stimulation to prevent hypoxia induced apneas.

methodsPreterm rabbit kittens were prematurely delivered and randomized to either group. All kittens breathed spontaneously with a positive airway pressure of 8 cmH

resultsAnticipatory stimulation significantly reduced apnea incidence and maximum inter-breath intervals and increased BR following IB, compared to reactive stimulation. Recovery in BR but not HR was more likely with anticipatory stimulation, although both BR and HR were significantly higher at 120 s after stimulation onset. FRC values and variability were not different.

conclusionsAnticipated vibrotactile stimulation is more effective in preventing apnea and enhancing breathing when compared to reactive stimulation in preterm rabbits. Stimulation timing is likely to be a key factor in reducing the incidence and duration of apnea. IMPACT: Anticipated vibrotactile stimulation can prevent apnea and stimulate breathing effort in preterm rabbits. Anticipated vibrotactile stimulation increases the likelihood of breathing rate recovery following hypoxia induced irregular breathing, when compared to reactive stimulation. Automated stimulation in combination with predictive algorithms may improve the treatment of apnea in preterm infants.

Indexed as

Animals, NewbornApneaHeart RateHypoxiaVibrationAnimalsDisease Models, AnimalFemaleFunctional Residual CapacityPhysical StimulationPremature BirthRabbitsRespirationRespiratory Rate

Identifiers

PMID38356025
OpenAlexW4391808874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.