Evidence map›Paper›PMID 38355951›Full record

ArticleScientific reports2024

Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy.

Pin-Yan Kuo, Hsin-Hsi Tsai, Bo-Ching Lee, Pu-Tien Chiang, Chia-Ju Liu, Ya-Fang Chen, Jiann-Shing Jeng, Ruoh-Fang Yen, Li-Kai Tsai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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  16. Clinical Management of Cerebral Amyloid Angiopathy.Journal of clinical medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Pin-Yan KuoDepartment of Medical Education, National Taiwan University Hospital, Taipei, Taiwan.
Hsin-Hsi TsaiDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan. hsinhsi@ntu.edu.tw.
Bo-Ching LeeDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Pu-Tien ChiangDepartment of Neurology, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan.
Chia-Ju LiuDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Ya-Fang ChenDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Jiann-Shing JengDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Ruoh-Fang YenDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Li-Kai TsaiDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
National Taiwan University Hospital · TW

Funding

National Science and Technology Council 112-2314-B-002-010National Science and Technology Council 112-2923-B-002-001-MY3National Taiwan University Hospital 113-N0075 and 113-X0018
6 · The paper itself

Abstract

Lobar cerebral microbleeds are a characteristic neuroimaging finding in cerebral amyloid angiopathy (CAA) but can also be found in hypertensive arteriolosclerosis. We aimed to investigate whether CAA is more associated with intracortical lobar microbleeds than hypertensive arteriosclerosis. Ninety-one survivors of spontaneous intracerebral hemorrhage with at least one lobar microbleed were included and underwent brain MRI and amyloid PET. We categorized lobar microbleeds as intracortical, juxtacortical, or subcortical. We assessed the associations between the lobar microbleed categories and microangiopathy subtypes or cerebral amyloid load based on the Pittsburgh Compound-B PET standardized uptake value ratio (SUVR). Patients with CAA had a higher prevalence of intracortical lobar microbleeds (80.0% vs. 50.8%, P = 0.011) and lower prevalence of subcortical lobar microbleeds (13.3% vs. 60.1%, P < 0.001) than patients with hypertensive arteriolosclerosis. Strictly intracortical/juxtacortical lobar microbleeds were associated with CAA (OR 18.9 [1.9-191.4], P = 0.013), while the presence of subcortical lobar microbleeds was associated with hypertensive arteriolosclerosis (OR 10.9 [1.8-68.1], P = 0.010). Amyloid retention was higher in patients with strictly intracortical/juxtacortical CMBs than those without (SUVR = 1.15 [1.05-1.52] vs. 1.08 [1.02-1.19], P = 0.039). Amyloid retention positively correlated with the number of intracortical lobar microbleeds (P < 0.001) and negatively correlated with the number of subcortical lobar microbleeds (P = 0.018). CAA and cortical amyloid deposition are more strongly associated with strictly intracortical/juxtacortical microbleeds than subcortical lobar microbleeds. Categorization of lobar microbleeds based on anatomical location may help differentiate the underlying microangiopathy and potentially improve the accuracy of current neuroimaging criteria for cerebral small vessel disease.

Indexed as

ArteriolosclerosisCerebral Amyloid AngiopathyHypertensionAmyloidAmyloidogenic ProteinsCerebral HemorrhageHumansMagnetic Resonance ImagingAmyloidAmyloidogenic ProteinsCerebral amyloid angiopathyCerebral microbleedHypertensionIntracerebral hemorrhagePittsburgh Compound BSmall vessel disease

Identifiers

PMID38355951
PMCPMC10866968
OpenAlexW4392783512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.