Evidence map›Paper›PMID 38355940›Full record

ArticleScientific reports2024

Follow-up of intramyocardial bone marrow mononuclear cell transplantation beyond 10 years.

Severi Mulari, Risto Kesävuori, Juhani A Stewart, Pasi Karjalainen, Miia Holmström, Miia Lehtinen, Juha Peltonen, Mika Laine, Juha Sinisalo, Tatu Juvonen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Severi MulariHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Risto KesävuoriDepartment of Radiology, HUS Medical Imaging Center and Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Juhani A StewartHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Pasi KarjalainenHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Miia HolmströmDepartment of Radiology, HUS Medical Imaging Center and Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Miia LehtinenHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Juha PeltonenDepartment of Radiology, HUS Medical Imaging Center and Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Mika LaineHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Juha SinisaloHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Tatu JuvonenHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Markku KupariHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Ari HarjulaHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Tommi PätiläPediatric Cardiac Surgery, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Sari KivistöDepartment of Radiology, HUS Medical Imaging Center and Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Esko KankuriFaculty of Medicine, Department of Pharmacology, University of Helsinki, Haartmaninkatu 8, PO Box 63, 00014, Helsinki, Finland. esko.kankuri@helsinki.fi.
Antti VentoHeart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Helsinki BMMC Collaboration

Funding

Finnish government subsidies for medical research block grants-awarded funding TYH2021346
6 · The paper itself

Abstract

Bone marrow mononuclear cells (BMMCs) have been evaluated for their ability to improve cardiac repair and benefit patients with severe ischemic heart disease and heart failure. In our single-center trial in 2006-2011 we demonstrated the safety and efficacy of BMMCs injected intramyocardially in conjunction with coronary artery bypass surgery. The effect persisted in the follow-up study 5 years later. In this study, we investigated the efficacy of BMMC therapy beyond 10 years. A total of 18 patients (46%) died during over 10-years follow-up and 21 were contacted for participation. Late gadolinium enhancement cardiac magnetic resonance imaging (CMRI) and clinical evaluation were performed on 14 patients, seven from each group. CMRIs from the study baseline, 1-year and 5-years follow-ups were re-analyzed to enable comparison. The CMRI demonstrated a 2.1-fold larger reduction in the mass of late gadolinium enhancement values between the preoperative and the over 10-years follow-up, suggesting less scar or fibrosis after BMMC treatment (- 15.1%; 95% CI - 23 to - 6.7% vs. - 7.3%; 95% CI - 16 to 4.5%, p = 0.039), compared to placebo. No differences in mortality or morbidity were observed. Intramyocardially injected BMMCs may exert long-term benefits in patients with ischemic heart failure. This deserves further evaluation in patients who have received BMMCs in international clinical studies over two decades.

Indexed as

Bone MarrowHeart FailureBone Marrow TransplantationCell TransplantationContrast MediaFollow-Up StudiesGadoliniumHumansTreatment OutcomeContrast MediaGadolinium

Identifiers

PMID38355940
PMCPMC10866866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.