ArticleNature2024
Deep whole-genome analysis of 494 hepatocellular carcinomas.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
32.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 114 citations in OpenAlex.
- IRDRM: Exploring Biological Traits and Clinical Significance in Breast Cancer Through Gene Pairs and Somatic Mutation Profiles.Interdisciplinary sciences, computational life sciences · 2026Article
- KGLAR: Deconvoluting Spatial Transcriptomics Data with Single-cell Transcriptomes through Knowledge-guided NMF and Least Angle Regression.Interdisciplinary sciences, computational life sciences · 2026Article
- ResNet-Powered Multi-Class Identification of Sequence Patterns for Genome Replication Timing Analysis.Interdisciplinary sciences, computational life sciences · 2026Article
- HBV integration into KMT2B increases malignant phenotype of hepatocellular carcinoma by epigenetic reprogramming.Cell insight · 2026Article
- YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations.Communications biology · 2026Article
- TERT drives liver tumorigenesis beyond telomere elongation.Life science alliance · 2026Article
- Biallelic loss of RB1 in hepatocellular carcinoma as synthetic lethal target for artificial intelligence-guided therapy.Signal transduction and targeted therapy · 2026Article
- HBV-induced miR-4461 downregulation correlates with elevated fibrinogen alpha chain expression in hepatocellular carcinoma.Journal of gastroenterology · 2026Article
- The TAF3/SREBP2/cholesterol axis drives tumor progression in hepatocellular carcinoma.Clinical and experimental medicine · 2026Article
- [Clinical significance and occurrence mechanism of hepatitis B virus DNA integration].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Molecular Pathophysiology of Hepatocellular Carcinoma: From Metabolic Inflammation to Therapeutic Targets.Cancers · 2026Review
- Late-stage dedifferentiation and epigenetic memory of cancer stem cells in hepatocellular carcinoma.Journal of translational medicine · 2026Article
- Artificial intelligence-driven integration of multi-biofluid omics and clinical phenotype enables stratification of endometrial cancer.Cell reports. Medicine · 2026Article
- A bibliometric analysis of extrachromosomal DNA in cancer over six decades.Discover oncology · 2026Article
- Upregulation of limb-bud and heart (LBH) drives liver cancer progression by interacting with the oncoprotein Mortalin.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Aristolochic Acid and Hepatocellular Carcinoma: A Critical Review of Genotoxic and Inflammatory Mechanisms.International journal of molecular sciences · 2026Review
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- Reinvigorating COTL1Nature cell biology · 2026Article
- The inwardly rectifying potassium channel KCNJ12 regulates the stemness of hepatocellular carcinoma cells through the Wnt/β-catenin pathway.Journal of molecular cell biology · 2026Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 10 institutions in 4 countries.
Lei Chen *National Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China. chenlei@smmu.edu.cn.ORCID 0000-0002-9380-9559
Chong Zhang *Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University, Beijing, China.ORCID 0000-0001-5072-5219
Ruidong Xue *Peking University-Yunnan Baiyao International Medical Research Center, International Cancer Institute, Department of Medical Bioinformatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.ORCID 0000-0002-5743-805X
Mo Liu *Centre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-5990-6585
Jian Bai *Berry Oncology Corporation, Beijing, China.
Jinxia Bao *Model Animal Research Center, Medical School, Nanjing University, Nanjing, China.
Yin Wang *Berry Oncology Corporation, Beijing, China.ORCID 0000-0001-8586-9714
Nanhai JiangCentre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-4974-2753
Zhixuan LiNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Wenwen WangThe International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Ruiru WangBerry Oncology Corporation, Beijing, China.
Bo ZhengNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Airong YangBerry Oncology Corporation, Beijing, China.
Ji HuNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Ke LiuBerry Oncology Corporation, Beijing, China.
Siyun ShenNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Yangqianwen ZhangNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Mixue BaiNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Yan WangBerry Oncology Corporation, Beijing, China.
Yanjing ZhuNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Shuai YangNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Qiang GaoDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-6695-9906
Jin GuMOE Key Laboratory for Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.ORCID 0000-0003-3968-8036
Dong GaoState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, CAS, Shanghai, China.ORCID 0000-0003-1821-2741
Xin Wei WangLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-9735-606X
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0003-1807-772X
Ning ZhangPeking University-Yunnan Baiyao International Medical Research Center, International Cancer Institute, Department of Medical Bioinformatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.ORCID 0000-0001-7182-0100
Lin WuBerry Oncology Corporation, Beijing, China. wulin@berryoncology.com.ORCID 0000-0002-8148-6713
Steven G RozenCentre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore. steve.rozen@duke-nus.edu.sg.ORCID 0000-0002-4288-0056
Fan BaiBiomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University, Beijing, China. fbai@pku.edu.cn.ORCID 0000-0001-6119-8936
Hongyang WangNational Center for Liver Cancer/Eastern Hepatobiliary Surgery Hospital, Shanghai, China. hywangk@vip.sina.com.ORCID 0000-0002-4709-3334
Second Military Medical University · CNBerry Oncology (China) · CNPeking University · CNDuke-NUS Medical School · SGCenter for Excellence in Molecular Cell Science · CNFudan University · CNModel Animal Research Center · CNNational Cancer Institute · USRIKEN Center for Integrative Medical Sciences · JPTsinghua University · CN
Funding
Strategies for improving early detection, diagnosis and treatment of liver cancerZIABC010313 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, XIN WEI · 2009 to 2025
$18.1MThe role of cancer stem cells in liver cancer heterogeneity and subtypesZIABC010876 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, XIN WEI · 2009 to 2025
$12.6MAbstract
Over half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China
Indexed as
Carcinoma, HepatocellularGenome, HumanHigh-Throughput Nucleotide SequencingLiver NeoplasmsMutationWhole Genome SequencingAristolochic AcidsCarcinogenesisChinaChromothripsisDisease ProgressionDNA, CircularEast Asian PeopleEvolution, MolecularHepatitis B virusHumansAristolochic AcidsDNA, Circular
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.