ArticleNature2024
Bone marrow plasma cells require P2RX4 to sense extracellular ATP.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Single-cell architecture of purinergic signaling in human cord blood hematopoietic stem and progenitor cells.Leukemia · 2026Article
- Cell intrinsic versus cell extrinsic control of plasma cell longevity.Trends in immunology · 2026Review
- Pannexin 3-mediated adenosine triphosphate release from pre-osteoblasts promotes osteoblast differentiation through P2X4 receptor activation.Frontiers in physiology · 2026Article
- Why are long-lived plasma cells long-lived?Frontiers in immunology · 2026Review
- ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases.Journal of inflammation research · 2026Review
- Quantitative LFQ-DIA proteomics reveals FTH1-MCM5/WNT axis mediated osteoblastic dysfunction via ferroptosis drives diabetic osteoporosis.Scientific reports · 2025Article
- Research progress on chimeric antigen receptor-based immunotherapy against autoimmune diseases.Human vaccines & immunotherapeutics · 2025Review
- eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron-Mediated Lung-to-Brain Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- P2RX4 promotes hepatocellular carcinoma progression via calcium-mediated PI3K/AKT activation and immune remodeling.World journal of surgical oncology · 2025Article
- Editorial: Purinergic signalling-a perspective from China (II).Purinergic signalling · 2025Article
- Review
- Possible Roles for Purinergic Receptor P2RX4 in Breast and Prostate Cancers.International journal of molecular sciences · 2025Review
- Engineering B cells to treat and study human disease.Nature biotechnology · 2025Review
- Early, adjuvant-responsive epigenetic programs in B cells imprint subsequent plasma cell survival and the duration of humoral immunity.bioRxiv : the preprint server for biology · 2025Article
- Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.Nature communications · 2025Article
- Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice.PLoS biology · 2025Article
- Distinct mural cells and fibroblasts promote pathogenic plasma cell accumulation in idiopathic pulmonary fibrosis.The European respiratory journal · 2025Article
- Research progress of CD73-adenosine signaling regulating hepatocellular carcinoma through tumor microenvironment.Journal of experimental & clinical cancer research : CR · 2025Review
- Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs.Bone research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Masaki IshikawaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. masaki.ishikawa@pennmedicine.upenn.edu.ORCID 0000-0003-3276-9474
Zainul S HasanaliDepartment of Medicine, Division of Hematology Oncology, Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9150-089X
Yongge ZhaoLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4466-2391
Arundhoti DasLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8574-9368
Marieke LavaertLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Carly J RomanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Jennifer LondreganDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2236-3577
David AllmanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. dallman@pennmedicine.upenn.edu.ORCID 0000-0001-9345-1502
Avinash BhandoolaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. avinash.bhandoola@nih.gov.ORCID 0000-0002-4657-8372
National Institutes of Health · USUniversity of Pennsylvania · US
Funding
T cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5MHEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1MTRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6MVery early plasma cell differentiationR01AI139123 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, ARGON, YAIR · 2018 to 2022
$3.0MBiochemical Mechanisms for Sustained Humoral ImmunityR01AI175185 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI David M Allman · 2023 to 2026
$2.5MPlasma Cell Regulation by Purinergic ReceptorsR21AI161931 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M · 2021 to 2022
$447kNotch2 Amplification of B Cell Division and Differentiation FatesF31AI179166 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LONDREGAN, JENNIFER · 2024 to 2025
$74kNHLBI NIH HHS T32 HL007439NIAID NIH HHS F31 AI179166NIAID NIH HHS R01 AI139123NIAID NIH HHS R01 AI175185NIAID NIH HHS R21 AI161931NIAID NIH HHS T32 AI007632
Abstract
Plasma cells produce large quantities of antibodies and so play essential roles in immune protection
Indexed as
Adenosine TriphosphateBone Marrow CellsPlasma CellsActivating Transcription Factor 4AnimalsAutoantibodiesAutoimmunityCell LineageConnexinsEndoplasmic ReticulumEndoplasmic Reticulum StressMiceMutationOsteoblastsReceptors, Purinergic P2X4Signal TransductionActivating Transcription Factor 4Adenosine TriphosphateAtf4 protein, mouseAutoantibodiesConnexinsDdit3 protein, mouseP2rx4 protein, mousepannexin 3 protein, mouseReceptors, Purinergic P2X4Transcription Factor CHOP
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.